Oxaliplatin‐induced peripheral neuropathy (OIPN) is a common and dose‐limiting toxic effect that markedly limits the use of oxaliplatin and affects the quality of life. Although it is common, the underlying mechanisms of OIPN remain ambiguous. Recent studies have shown that the platinum accumulation in peripheral nervous system, especially in dorsal root ganglion, is a significant mechanism of OIPN. Several specific transporters, including organic cation transporters, high‐affinity copper uptake protein1 (CTR1), ATPase copper transporting alpha (ATP7A) and multidrug and toxin extrusion protein 1 (MATE1), could be associated with this mechanism. This review summarizes the current research progress about the relationship between platinum accumulation and OIPN, as well as suggests trend for the future research.

中文翻译：

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奥沙利铂引起的周围神经病变中铂的蓄积

奥沙利铂引起的周围神经病变（OIPN）是一种常见的剂量限制性毒性作用，显着限制奥沙利铂的使用并影响生活质量。尽管很常见，但 OIPN 的基本机制仍然不明确。最近的研究表明，铂在周围神经系统尤其是背根神经节中的积累是OIPN的重要机制。几种特定的转运蛋白，包括有机阳离子转运蛋白、高亲和力铜摄取蛋白 1 (CTR1)、ATP 酶铜转运 α (ATP7A) 和多药物和毒素挤出蛋白 1 (MATE1)，可能与该机制有关。本文综述了目前铂积累与OIPN关系的研究进展，并提出了未来的研究趋势。