The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the etiological agent for the Coronavirus Disease 2019 (COVID‐19). The COVID‐19 pandemic has created unimaginable and unprecedented global health crisis. Since the outbreak of COVID‐19, millions of dollars have been spent, hospitalization overstretched with increasing morbidity and mortality. All these have resulted in unprecedented global economic catastrophe. Several drugs and vaccines are currently being evaluated, tested, and administered in the frantic efforts to stem the dire consequences of COVID‐19 with varying degrees of successes. Zinc possesses potential health benefits against COVID‐19 pandemic by improving immune response, minimizing infection and inflammation, preventing lung injury, inhibiting viral replication through the interference of the viral genome transcription, protein translation, attachment, and host infectivity. However, this review focuses on the various mechanisms of action of zinc and its supplementation as adjuvant for vaccines an effective therapeutic regimen in the management of the ravaging COVID‐19 pandemic.

中文翻译：

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补充锌对管理COVID-19大流行的潜在健康益处

严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）是2019年冠状病毒病（COVID-19）的病原体。COVID-19大流行造成了无法想象的，前所未有的全球卫生危机。自从COVID-19爆发以来，已经花费了数百万美元，因过度使用而增加了发病率和死亡率。所有这些都导致了前所未有的全球经济灾难。目前正在疯狂地评估，测试和管理几种药物和疫苗，以阻止COVID-19的严重后果，并取得不同程度的成功。锌具有改善COVID-19大流行的潜在健康益处，可改善免疫反应，减少感染和炎症，预防肺损伤，通过干扰病毒基因组转录，蛋白质翻译，附着和宿主感染性来抑制病毒复制。但是，本综述着眼于锌的各种作用机制及其作为疫苗佐剂的补充，是管理严重的COVID-19大流行的有效治疗方案。