The prevalence of liver disease is increasing year by year and it is recognized as a main health burden across the world. Nowadays, dietary nutraceuticals are found to be very effective in the prevention and treatment of liver diseases. The virgin coconut oil and phosphatidylcholine are found to have a wide range of therapeutic efficacy and the most important among them is its hepatoprotective activity. In the present study, we had evaluated the hepatoprotective effect of the novel formulation with the combination of these two which is named as Phoscoliv. For the study, adult Wistar rats were grouped into Normal control, Paracetamol‐treated, and Paracetamol along with Phoscoliv‐treated group. In order to evaluate the hepatoprotective effect of the drug, various parameters were analyzed. Data obtained from the study showed that Phoscoliv supplementation were found to significantly boost up the antioxidant status by enhancing the SOD, CAT, GPx, and GSH level and thereby inhibit the generation of ROS and also blocked lipid peroxidation, which was confirmed by the reduced level of TBARS. The release of pro‐inflammatory cytokines was also decreased, which was eventually helped to maintain the normal architecture of the liver. Thus, from the overall result of this study reveals that Phoscoliv can be effectively used as a potent and safe hepatoprotective medicine.

中文翻译：

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富含初榨椰子油（Phoscoliv）的必需磷脂对扑热息痛引起的肝毒性的肝保护作用

肝病的患病率逐年增加，被认为是全世界的主要健康负担。如今，饮食中的营养保健品在预防和治疗肝病方面非常有效。发现原始椰子油和磷脂酰胆碱具有广泛的治疗功效，其中最重要的是其保肝活性。在本研究中，我们已经评估了新型制剂与这两种名为Phoscoliv的组合的保肝作用。为了进行研究，将成年的Wistar大鼠分为正常对照组，扑热息痛治疗的组和扑热息痛以及Phoscoliv治疗组。为了评估药物的肝保护作用，分析了各种参数。从研究中获得的数据表明，通过增加SOD，CAT，GPx和GSH的水平，发现添加Phoscoliv可以显着提高抗氧化剂的状态，从而抑制ROS的生成，并阻止脂质过氧化，这一点已得到证实。 TBARS。促炎细胞因子的释放也减少了，这最终有助于维持肝脏的正常结构。因此，从这项研究的总体结果表明，Phoscoliv可以有效地用作有效且安全的肝保护药物。促炎细胞因子的释放也减少了，最终有助于维持肝脏的正常结构。因此，从这项研究的总体结果表明，Phoscoliv可以有效地用作有效且安全的肝保护药物。促炎细胞因子的释放也减少了，最终有助于维持肝脏的正常结构。因此，从这项研究的总体结果表明，Phoscoliv可以有效地用作有效且安全的肝保护药物。