COVER ILLUSTRATION Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with highly heterogenous progression patterns. Presented are DTI contrasts of increased radial diffusivity for patients with ALS, that demonstrated a widespread white matter pathology if compared to healthy controls (top left). In Steinbach et al. the D50 disease progression model was applied which provides mathematically defined descriptors of the different progression types. It was used to quantify measures of disease covered independent from those of disease aggressiveness. Higher aggressiveness of patients' individual ALS disease was associated with elevated radial diffusivity in association tracts (top right). A positive correlation was found with the amount of disease covered (bottom left) as well as the calculated functional state (bottom right) at the day of MRI, representing individual disease accumulation early in disease. Harmonizing disease quantification by modelling thus greatly increased the sensitivity to identify ALS related brain disease.

中文翻译：

---

封面图片

封面插图肌萎缩性侧索硬化症（ALS）是一种进展性神经退行性疾病，具有高度异质的进展模式。呈现的是ALS患者放射扩散性增加的DTI对比，如果与健康对照相比，则显示出广泛的白质病理（左上方）。在Steinbach等。应用D50疾病进展模型，该模型提供了数学定义的不同进展类型的描述子。它用于量化与疾病侵袭性无关的疾病度量标准。患者个体ALS疾病的较高侵略性与关联区域的径向扩散性升高相关（右上）。发现与MRI当天所覆盖疾病的数量（左下）以及计算的功能状态（右下）呈正相关，代表了疾病早期的单个疾病累积。因此，通过建模协调疾病量化，大大提高了识别ALS相关脑疾病的敏感性。