3‐Bromo‐2‐hydroxybenzaldehyde has been used as an efficient transient directing group (TDG) in the Pd‐catalyzed sp³−C−H arylation of primary amines in γ‐position. These experimental findings have been corroborated by computational studies. Further functionalization (tandem oxidation) and synthetic application were also achieved with the presented Pd/TDG catalytic approach.

中文翻译：

---

Pd催化的脂族胺的立体和立体选择性sp3 CH芳基化：机理研究和合成应用

3-溴-2-羟基苯甲醛已被用作伯胺在Pd催化的sp ³ -C-H芳基化中的高效瞬态导向基团（TDG）。这些实验结果已通过计算研究得到证实。提出的Pd / TDG催化方法还实现了进一步的功能化（串联氧化）和合成应用。