The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon-carbon bonds. In its classical form, it uses a Pd catalyst as well as copper co-catalyst and amines as the solvents or co-solvents to form a carbon-carbon bond between a terminal alkyne and an aryl or vinyl halide. Due to the relatively high price of Pd and its toxicity, the Pd-free catalyzed Sonogashira cross-coupling reaction has attracted much attention from synthetic organic chemists, both in academia and industry. Several successful attempts have been made, which were introduced in a review article published in 2016. Due to a plethora of relevant papers that appeared in the chemical literature, in this review, we try to underline the recent advances achieved in the Pd-free Sonogashira reaction from 2016 to date.

Sonogashira反应是有机合成中用于形成碳-碳键的交叉偶联反应。在其经典形式中，它使用Pd催化剂以及铜助催化剂和胺作为溶剂或助溶剂，以在末端炔烃与芳基或乙烯基卤化物之间形成碳-碳键。由于Pd的价格相对较高且具有毒性，因此无Pd催化的Sonogashira交叉偶联反应已引起学术界和工业界有机合成化学家的广泛关注。进行了几次成功的尝试，并在2016年发表的一篇综述文章中进行了介绍。由于化学文献中出现了大量相关论文，在这篇综述中，我们试图强调无铅Sonogashira的最新进展。从2016年至今的反应。