In this study, we establish a novel highly efficient preparation process to prepare homogeneous and size controllable pH-responsive lignin nanosphere (LN). Orthogonal experiments have been performed to investigate the effects of the factors (bath temperature, lignin concentration, starting volume, cooling temperature) on the effective diameters (ED) and polydispersity index (PDI) of LN. The fast vacuum evaporation process could also encapsulate drugs in the one-pot process, with the solvent acetone recycled simultaneously. The drug release based on pH-responsive have been investigated. As a result, homogenous LN with targeted size (within 100 ∼ 400 nm) had been obtained under the preparation conditions suggested by the established Models. The matrix entrapment efficiency of LN was 47 %. The lignin encapsulating Ibuprofen nanospheres showed excellent pH-responsive release. It had just 18 % released at pH 1.2, while over 90 % at pH7.5 for 2−6 h. This study introduced a highly efficient way to prepare lignin nanospheres and a new strategy to prepare pH-responsive drugs.

在这项研究中，我们建立了一种新型的高效制备工艺，以制备均质且尺寸可控的pH响应木质素纳米球（LN）。已经进行了正交实验以研究因素（浴温，木质素浓度，起始体积，冷却温度）对LN的有效直径（ED）和多分散指数（PDI）的影响。快速真空蒸发过程还可以将药物封装在一锅过程中，同时溶剂丙酮可以循环使用。已经研究了基于pH响应的药物释放。结果，在建立的模型建议的制备条件下，获得了具有目标尺寸（在100〜400 nm之内）的均匀LN。LN的基质截留效率为47％。木质素包裹布洛芬纳米球表现出出色的pH响应释放。在pH 1.2时只有18％释放，而在pH7.5超过90％释放了2-6小时。这项研究介绍了一种制备木质素纳米球的高效方法和一种制备pH响应药物的新策略。