Currently, the main therapeutic method for cancer is still surgical resection. But tumors are difficult to be completely removed, leading to the recurrence of tumors and serious threat to human health. Thus, it is urgent to find appropriate methods for removing residual cancer. Herein, a multifunctional hydrogel is designed for photothermal therapy (PTT) combined with photodynamic therapy (PDT). Gold nanorods (AuNRs) and methylene blue (MB) were used as the PTT and PDT agents, respectively, and were loaded in hydrogels formed by Gellan Gum. Multiple advantages of this platform include (a) excellent photothermal and photodynamic properties, (b) satisfactory syringeability, (c) controllable mechanical properties and superior stability, (d) good cytocompatibility, (e) prevention of the rapid loss of nanomaterials and (f) good inhibition effect of cancer cells. Consequently, the multifunctional hydrogel has satisfying biocompatibility and high cancer cell ablation efficiency, showing tremendous potential in synergistic anticancer therapy.

目前，癌症的主要治疗方法仍是手术切除。但是很难将肿瘤彻底清除，导致肿瘤复发并严重威胁人类健康。因此，迫切需要找到适当的方法来去除残留的癌症。在此，多功能水凝胶被设计用于光热疗法（PTT）和光动力疗法（PDT）的组合。金纳米棒（AuNRs）和亚甲基蓝（MB）分别用作PTT和PDT试剂，并装载在Gellan Gum形成的水凝胶中。该平台的多项优势包括：（a）出色的光热和光动力特性；（b）令人满意的可注射性；（c）可控的机械特性和出色的稳定性；（d）良好的细胞相容性；（e）防止纳米材料的快速损失和（f）癌细胞的良好抑制作用。因此，多功能水凝胶具有令人满意的生物相容性和高的癌细胞消融效率，在协同抗癌治疗中显示出巨大的潜力。