Cgnz1 on chromosome 1 mapped into a 1.34 Mb region of chromosome 1 in NZM2328 confers the progression of immune complex (IC) mediated glomerulonephritis (GN) from acute GN (aGN) to chronic GN (cGN) with severe proteinuria and end stage renal disease in female mice. This genetic locus mediates podocyte susceptibility to IC mediated damage. Taking advantage of the published observation that Cgnz1 is derived from NZW and that NZW is susceptible to orchitis, epididymitis and vasitis while C57L/J is resistant to these diseases, the possibility that this genetic region also confers germ cells susceptible to damage with aspermatogenesis and sterility in an active experimental autoimmune orchitis (EAO) model was investigated. Male mice from multiple intrachromosome (chromosome 1) recombinant strains were subjected to immunization with a sperm homogenate in CFA with concomitant administration of Bordetella pertussis toxin. There was concordance of the progression from aGN to cGN, severe proteinuria and end stage renal disease with susceptibility of EAO in NZM2328 and its congenic strains with various chromosome 1 genetic intervals introgressed from C57L/J to NZM2328. Both resistant and susceptible strains made comparable anti-testis and anti-sperm Abs. Thus the genetic interval that determines susceptibility to EAO is identical to that of Cgnz1 and mapped to the 1.34 Mb region within C57B6.NZM2410Sle1b (Sle1b). This region likely confers germ cells in the male gonad susceptible to damage by immunological mediated inflammation. This region has been tentatively renamed Cgnz1/Eaoz1. These observations further emphasize the importance of end organ susceptibility to damage in the pathogenesis of both systemic and organ specific autoimmune diseases.

1 号染色体上的Cgnz1映射到 NZM2328 中 1 号染色体的 1.34 Mb 区域，使免疫复合物 (IC) 介导的肾小球肾炎 (GN) 从急性肾小球肾炎 (aGN) 进展为慢性肾小球肾炎 (cGN)，伴有严重的蛋白尿和终末期肾病雌性老鼠。该基因位点介导足细胞对 IC 介导的损伤的易感性。利用已发表的观察结果，即Cgnz1来自 NZW 并且 NZW 对睾丸炎、附睾炎和输精管炎敏感，而 C57L/J 对这些疾病有抵抗力，这个遗传区域也可能赋予生殖细胞在活动性实验性自身免疫性睾丸炎 (EAO) 中易受精子发生和不育损伤的可能性) 模型进行了研究。用 CFA 中的精子匀浆对来自多个染色体内（染色体 1）重组菌株的雄性小鼠进行免疫，同时给予百日咳博德特氏菌毒素。从aGN到cGN的进展、严重蛋白尿和终末期肾病与NZM2328中EAO的易感性及其具有从C57L/J到NZM2328的不同染色体1遗传区间渗入的同类菌株一致。抗性和易感菌株都产生了相当的抗睾丸和抗精子抗体。因此，决定对 EAO 易感性的遗传区间与 Cgnz1 的遗传区间相同，并映射到C57B6内的 1.34 Mb 区域。NZM2410Sle1b ( Sle1b ) 。该区域可能赋予男性性腺中的生殖细胞易受免疫介导炎症损伤的影响。该区域已暂时重命名为Cgnz1/Eaoz1。这些观察结果进一步强调了终末器官对损伤的易感性在全身性和器官特异性自身免疫疾病的发病机制中的重要性。