Bentonite (Bent) is a highly promising material to be used in the pharmaceutical industry as drug delivery system due to its high drug loading capacity and controlled drug release properties. The adsorption and controlled release of vancomycin (VCM) ―a glycopeptide antibiotic of large molecular size and structural complexity― on/from an unmodified Bent is reported. The adsorption and release of this drug on/from the Bent―whose safety was demonstrated by in vivo studies―was monitored by ultraviolet (UV) spectroscopy. In order to enhance the VCM loading by the clay, different physical-chemical parameters (pH, drug initial concentration, temperature and interaction time) were evaluated. The Bent-VCM composite was characterized by X-ray diffraction (XRD), transmittance Fourier transform infrared spectroscopy (FT-IR) and thermal gravimetric analysis (TGA). The results showed that the Bent is able to efficiently adsorb VCM, achieving a higher load (q_max= 655 ± 5 mg/g) at 9 × 10³ mg/L, when it is in its monovalent cationic form. The characterization studies indicated surface adsorption, as well as clay-drug interactions by hydrogen bridges and electrostatic forces. The Sips isotherm model exhibited a good correlation to the equilibrium experimental data, indicating heterogeneous adsorption of the adsorbate-adsorbent system under study. The ΔG⁰ calculation indicated the spontaneous and reversible nature of the adsorption process. The in vitro assays at pH values typical of the human gastrointestinal tract demonstrated that the VCM release profiles fulfill the pharmaceutical standards, suggesting the potential use of Bent as VCM carrier.

膨润土（Bent）具有很高的载药量和受控的药物释放特性，是一种非常有前途的材料，可在制药工业中用作药物输送系统。据报道，万古霉素（一种具有大分子尺寸和结构复杂性的糖肽抗生素）在未修饰的Bent上的吸附和控制释放。该药物在Bent上的吸附和从Bent的释放-体内的安全性证明了这一点研究-通过紫外线（UV）光谱进行监控。为了增加粘土对VCM的负载，评估了不同的物理化学参数（pH，药物初始浓度，温度和相互作用时间）。Bent-VCM复合材料的特征在于X射线衍射（XRD），透射傅立叶变换红外光谱（FT-IR）和热重分析（TGA）。结果表明，Bent能够有效吸附VCM，并在9×10 ^3时实现更高的负载（q _max = 655±5 mg / g）。 毫克/公升（单价阳离子形式）。表征研究表明表面吸附以及通过氢桥和静电力的粘土-药物相互作用。Sips等温线模型与平衡实验数据显示出良好的相关性，表明所研究的吸附物-吸附剂系统存在异质吸附。在ΔG ⁰计算表明吸附过程的自发的和可逆的性质。在体外测定中的pH值典型人类的胃肠道表明，VCM释放曲线符合药品标准，表明潜在用途排架作为VCM载体。