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Synthesis, characterization, antimicrobial and antifungal activity studies of two novel aminopyridine−sulfamoylbenzoic acid salts and their Cu(II) complexes
Journal of the Iranian Chemical Society ( IF 2.4 ) Pub Date : 2021-01-18 , DOI: 10.1007/s13738-021-02157-4
Halil İlkimen , Nagehan Türken , Aysel Gülbandılar

Two new proton transfer compounds, (H2a3mp)+(psba) (1) and (H2a3mp)+(2MeO5sba) (2), obtained from 2-amino-3-methylpyridine with (2a3mp) and p-sulfamoylbenzoic acid (Hpsba) or 2-methoxy-5-sulfamoylbenzoic acid (H2MeO5sba), respectively, and Cu(II) complexes of Hpsba (3), of H2MeO5sba (4), of 1 (5) and of 2 (6) were synthesized and characterized by FT-IR, UV, 1H-NMR, elemental, AAS, magnetic measurement and molar conductivity. Furthermore, free compounds, 2a3mp, Hpsba, 2MeO5sba and Cu(CH3COO)2·H2O, Cu(II) complex of 2a3mp (Cu2a3mp) and compounds (16) have been screened for their antifungal and antibacterial activities against Candida parapisilosis (ATCC 22019), Candida krusei (ATCC 6258) (yeast) and Enterococcus faecalis (ATCC 29212) Escherichia coli (ATCC 25922) (Gram negative), Staphylococcus aureus (ATCC 29213) (Gram positive). The results are touched with standard antifungal agent (Fluconazole) and antibacterial agents (Cefepime, Vancomycin and Levofloxacin).



中文翻译:

两种新型氨基吡啶-氨磺酰基苯甲酸盐及其Cu(II)配合物的合成,表征,抗菌和抗真菌活性研究

两种新的质子转移化合物(H2a3mp)+(psba)-1)和(H2a3mp)+(2MeO5sba)-2)从2-氨基-3-甲基吡啶与(2a3mp)和对氨基磺酰基苯甲酸(Hpsba)获得)或2-甲氧基-5-氨磺酰基苯甲酸(H2MeO5sba),分别合成Hpsba(3),H2MeO5sba(4),15)和26)的Cu(II)配合物,并进行表征FT-IR,UV,1 H-NMR,元素,AAS,磁测量和摩尔电导率。此外,还有游离化合物2a3mp,Hpsba,2MeO5sba和Cu(CH 3COO)2 ·H 2 O,铜(II)络合物2a3mp(Cu2a3mp)和化合物(的1 - 6)已经被筛选针对其的抗真菌和抗菌活性念珠菌parapisilosis(ATCC 22019),克鲁斯假丝酵母(ATCC 6258)(酵母)和粪肠球菌(ATCC 29212)大肠杆菌(ATCC 25922)(革兰氏阴性),金黄色葡萄球菌(ATCC 29213)(革兰氏阳性)。结果与标准抗真菌药(氟康唑)和抗菌剂(头孢吡肟,万古霉素和左氧氟沙星)有关。

更新日期:2021-01-19
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