Miniature yoked eye movements, fixational saccades, are critical to counteract visual fading. Fixational saccades are followed by a return saccades forming squarewaves. Present in healthy states, squarewaves, if too many or too big, affect visual stability. Parkinson’s disease (PD), where visual deficits are not uncommon, is associated with the squarewaves that are excessive in number or size. Our working hypothesis is that the basal ganglia are at the epicenter of the abnormal fixational saccades and squarewaves in PD; the effects are manifested through their connections to the superior colliculus (affecting saccade frequency and amplitude) and the cerebellum (affecting velocity and amplitude). We predict that the subthalamic deep brain stimulation (DBS) variably affects the amplitude, frequency, and velocity of fixational saccade and that the effect depends on the electrode’s proximity or the volume of activated tissue in the subthalamic nucleus’ connections with the superior colliculus or the cerebellum. We found that DBS modulated saccade amplitude, frequency, and velocity in 11 PD patients. Although all three parameters were affected, the extent of the effects varied amongst subjects. The modulation was dependent upon the location and size of the electrically activated volume of the subthalamic region.

微型轭眼运动、注视眼跳对于抵消视觉衰退至关重要。注视扫视之后是形成方波的返回扫视。方波在健康状态下存在，如果过多或过大，都会影响视觉稳定性。帕金森氏病 (PD) 的视觉缺陷并不少见，与数量或大小过多的方波有关。我们的工作假设是基底神经节位于 PD 异常注视跳视和方波的中心；这些影响通过它们与上丘（影响跳视频率和幅度）和小脑（影响速度和幅度）的连接而表现出来。我们预测丘脑深部脑刺激 (DBS) 会可变地影响振幅、频率、和固定眼跳的速度，其效果取决于电极的接近程度或丘脑底核与上丘或小脑的连接中激活组织的体积。我们发现 DBS 调制了 11 名 PD 患者的跳视幅度、频率和速度。尽管所有三个参数都受到影响，但影响的程度因受试者而异。调制取决于丘脑底区域的电激活体积的位置和大小。影响的程度因受试者而异。调制取决于丘脑底区域的电激活体积的位置和大小。影响的程度因受试者而异。调制取决于丘脑底区域的电激活体积的位置和大小。