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Does contemporary ART lead to pre-eclampsia? A cohort study and meta-analysis
Journal of Assisted Reproduction and Genetics ( IF 3.1 ) Pub Date : 2021-01-19 , DOI: 10.1007/s10815-021-02061-z
Shlomit Kenigsberg 1 , Yaakov Bentov 1, 2, 3
Affiliation  

Purpose

Recent publications suggested that the risk for pre-eclampsia (PE) is higher with frozen-thawed embryo transfers (FETs) compared to fresh transfers (IVF-ETs). These studies were based on old data that reflects outdated practices. In this paper, we wanted to assess the incidence of PE in current assisted reproductive technology (ART) practice.

Methods

In this cohort study, we present the incidence of PE in all births in the province of Ontario, Canada, for the years 2013–2017 for FET, IVF-ET, and natural conceptions (NC). We also compare our findings to previous studies in a meta-analysis that includes over 4 million births.

Results

The results of our study show that contemporary practice of ART results in comparable risk for PE between FET and IVF-ET; however, the risk is higher than NC.

Conclusion

Current ART practice is associated with a lower risk for PE in frozen embryo transfer; this RR can be further attenuated by using ovulatory endometrial preparation for FETs.



中文翻译:

当代艺术会导致先兆子痫吗?队列研究和荟萃分析

目的

最近的出版物表明,与新鲜移植 (IVF-ET) 相比,冻融胚胎移植 (FET) 的先兆子痫 (PE) 风险更高。这些研究基于反映过时做法的旧数据。在本文中,我们想评估当前辅助生殖技术 (ART) 实践中 PE 的发生率。

方法

在这项队列研究中,我们展示了 2013-2017 年加拿大安大略省所有新生儿中 FET、IVF-ET 和自然受孕 (NC) 的 PE 发病率。我们还在一项包括超过 400 万例新生儿的荟萃分析中将我们的研究结果与之前的研究进行了比较。

结果

我们的研究结果表明,当代 ART 实践导致 FET 和 IVF-ET 之间的 PE 风险相当;但是,风险高于NC。

结论

目前的 ART 实践与冷冻胚胎移植中 PE 的较低风险相关;这种 RR 可以通过使用 FET 的排卵子宫内膜制剂进一步减弱。

更新日期:2021-01-19
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