This work establishes that in comparison with the popular synthetic synthon tetra-p-hydroxyphenyl porphyrin (THPP), used for developing various cancer photodynamic therapy (PDT) agents, the cis-A₂B₂ type porphyrin derivative, synthesized by replacing two p-hydroxyphenyl groups at the meso-positions with two p-nitrophenyl moieties, 5,10-bis-(4-hydroxyphenyl)-15,20-bis-(4-nitrophenyl)porphyrin PN₂(OH)₂ and its zinc(II) complex PN₂(OH)₂Zn have more promising photosensitizing and photobiological activities. The presence of the electron-withdrawing p-nitrophenyl moiety seems to strengthen and influence the photodynamic therapy (PDT) action against the A549 cell line by upregulating reactive oxygen species (ROS) and downregulating superoxide dismutase (SOD) in the same cancer cell line. Further, murine macrophage myeloperoxidase (MPO) inhibition and nitric oxide (NO) downregulation by PN₂(OH)₂ and PN₂(OH)₂Zn are indicative of a concomitant immunoprotective nature towards noncancerous cells.

中文翻译：

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顺式-A2B2型内消旋-对硝基苯基和对羟基苯基卟啉及其锌（II）配合物的光毒性和抗炎反应：THPP合成子的合成替代品

这项工作确立了与合成子四流行合成比较p羟苯基卟啉（THPP），用于开发各种癌症的光动力疗法（PDT）剂，所述顺式-A ₂乙₂型卟啉衍生物，通过用2个合成p -具有两个对硝基苯基部分，5,10-双-（4-羟基苯基）-15,20-双-（4-硝基苯基）卟啉PN ₂（OH）₂及其锌（II）的中间位置的羟基苯基复合PN ₂（OH）₂ Zn具有更广阔的光敏和光生物学活性。吸电子对硝基苯基部分的存在似乎通过在同一癌细胞系中上调活性氧（ROS）和下调超氧化物歧化酶（SOD）来增强和影响针对A549细胞系的光动力疗法（PDT）作用。此外，PN ₂（OH）₂和PN ₂（OH）₂ Zn对鼠巨噬细胞髓过氧化物酶（MPO）的抑制和一氧化氮（NO）的下调指示了对非癌细胞的免疫保护性。