The rational design of nanozymes as new “antibiotics” for bacterial therapy is a promising area in healthcare. Herein, B-doped core–shell Fe@BC nanozymes functioned with peroxidase-like activity for bacterial inhibition were studied. Experimental and theoretical results show that the BCO₂ site enables a much lower energy barrier than the BC₂O site, with a positive correlation between the density and activity of BCO₂. The enzyme-like and positively-charged properties of core–shell Fe@BC improve the production and utilization of ˙OH to efficiently kill bacteria. This study not only highlights a promising peroxidase mimic for hygiene management but also deepens the understanding of B-doped carbon nanozymes.

中文翻译：

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B掺杂核壳Fe @ BC纳米酶：活性位点鉴定和细菌抑制

纳米酶作为细菌治疗的新“抗生素”的合理设计在医疗保健领域是一个充满希望的领域。在本文中，研究了具有过氧化物酶样活性的B掺杂核壳Fe @ BC纳米酶对细菌的抑制作用。实验和理论结果表明，BCO ₂位点的能垒比BC ₂ O位点低得多，并且BCO ₂的密度和活性之间呈正相关。核-壳Fe @ BC的类酶和带正电荷的特性可提高˙OH的产生和利用，从而有效地杀死细菌。这项研究不仅强调了用于卫生管理的有希望的过氧化物酶模拟物，而且加深了对掺B碳纳米酶的理解。