Miniaturized microscopes for head-mounted fluorescence imaging are powerful tools for visualizing neural activity during naturalistic behaviors, but the restricted field of view of first-generation "miniscopes" limits the size of neural populations accessible for imaging. Here we describe a novel miniaturized mesoscope offering cellular-resolution imaging over areas spanning several millimeters in freely moving mice. This system enables comprehensive visualization of activity across entire brain regions or interactions across areas.

中文翻译：

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自由行为小鼠神经活动的大规模细胞分辨率成像

用于头戴式荧光成像的微型显微镜是在自然行为期间可视化神经活动的强大工具，但是第一代“微型显微镜”的受限视野限制了可成像的神经种群的数量。在这里，我们描述了一种新型的小型介电镜，可在自由移动的小鼠中提供跨越几毫米区域的细胞分辨率成像。该系统可以全面可视化整个大脑区域的活动或跨区域的交互。