Ten-eleven translocation-2 (TET2) is a crucial driver of cell fate outcomes in a myriad of biological processes, including embryonic development and tissue homeostasis. TET2 catalyzes the demethylation of 5-methylcytosine on DNA, affecting transcriptional regulation. New exciting research has provided evidence for TET2 catalytic activity in post-transcriptional regulation through RNA hydroxymethylation. Here we review the current understanding of TET2 functions on both DNA and RNA, and the influence of these chemical modifications in normal development and pluripotency contexts, highlighting TET2 versatility in influencing genome regulation and cellular phenotypes.

10-11易位2（TET2）是无数生物过程（包括胚胎发育和组织动态平衡）中细胞命运结局的关键驱动力。TET2催化DNA上的5-甲基胞嘧啶脱甲基，影响转录调控。新的令人兴奋的研究为TET2在通过RNA羟甲基化的转录后调控中的催化活性提供了证据。在这里，我们回顾了目前对TET2在DNA和RNA上的功能的理解，以及这些化学修饰对正常发育和多能性环境的影响，突出了TET2在影响基因组调控和细胞表型方面的多功能性。