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The Role of Microenvironmental Cues and Mechanical Loading Milieus in Breast Cancer Cell Progression and Metastasis
Frontiers in Bioengineering and Biotechnology ( IF 5.7 ) Pub Date : 2021-01-18 , DOI: 10.3389/fbioe.2020.608526 Brandon D. Riehl , Eunju Kim , Tasneem Bouzid , Jung Yul Lim
Frontiers in Bioengineering and Biotechnology ( IF 5.7 ) Pub Date : 2021-01-18 , DOI: 10.3389/fbioe.2020.608526 Brandon D. Riehl , Eunju Kim , Tasneem Bouzid , Jung Yul Lim
Cancer can disrupt the microenvironments and mechanical homeostatic actions in multiple scales from large tissue modification to altered cellular signaling pathway in mechanotransduction. In this review, we highlight recent progresses in breast cancer cell mechanobiology focusing on cell-microenvironment interaction and mechanical loading regulation of cells. First, the effects of microenvironmental cues on breast cancer cell progression and metastasis will be reviewed with respect to substrate stiffness, chemical/topographic substrate patterning, and 2D vs. 3D cultures. Then, the role of mechanical loading situations such as tensile stretch, compression, and flow-induced shear will be discussed in relation to breast cancer cell mechanobiology and metastasis prevention. Ultimately, the substrate microenvironment and mechanical signal will work together to control cancer cell progression and metastasis. The discussions on breast cancer cell responsiveness to mechanical signals, from static substrate and dynamic loading, and the mechanotransduction pathways involved will facilitate interdisciplinary knowledge transfer, enabling further insights into prognostic markers, mechanically mediated metastasis pathways for therapeutic targets, and model systems required to advance cancer mechanobiology.
中文翻译:
微环境线索和机械负荷环境在乳腺癌细胞进展和转移中的作用
癌症可以在多个尺度上破坏微环境和机械稳态作用,从大的组织修饰到机械转导中改变的细胞信号通路。在这篇综述中,我们重点介绍了乳腺癌细胞力学生物学的最新进展,重点是细胞-微环境相互作用和细胞的机械负荷调节。首先,将从基质硬度、化学/地形基质图案和 2D 与 3D 培养方面审查微环境线索对乳腺癌细胞进展和转移的影响。然后,将讨论与乳腺癌细胞力学生物学和转移预防相关的机械载荷情况,如拉伸拉伸、压缩和流动诱导剪切的作用。最终,底物微环境和机械信号将共同控制癌细胞的进展和转移。关于乳腺癌细胞对来自静态基质和动态负载的机械信号的反应以及所涉及的机械转导途径的讨论将促进跨学科知识转移,使人们能够进一步了解预后标志物、治疗靶点的机械介导转移途径以及推进所需的模型系统癌症机械生物学。
更新日期:2021-01-18
中文翻译:
微环境线索和机械负荷环境在乳腺癌细胞进展和转移中的作用
癌症可以在多个尺度上破坏微环境和机械稳态作用,从大的组织修饰到机械转导中改变的细胞信号通路。在这篇综述中,我们重点介绍了乳腺癌细胞力学生物学的最新进展,重点是细胞-微环境相互作用和细胞的机械负荷调节。首先,将从基质硬度、化学/地形基质图案和 2D 与 3D 培养方面审查微环境线索对乳腺癌细胞进展和转移的影响。然后,将讨论与乳腺癌细胞力学生物学和转移预防相关的机械载荷情况,如拉伸拉伸、压缩和流动诱导剪切的作用。最终,底物微环境和机械信号将共同控制癌细胞的进展和转移。关于乳腺癌细胞对来自静态基质和动态负载的机械信号的反应以及所涉及的机械转导途径的讨论将促进跨学科知识转移,使人们能够进一步了解预后标志物、治疗靶点的机械介导转移途径以及推进所需的模型系统癌症机械生物学。