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Herpesvirus Infections and Risk of Parkinson’s Disease
Neurodegenerative Diseases ( IF 3 ) Pub Date : 2020-01-01 , DOI: 10.1159/000512874
Alejandra Camacho-Soto 1 , Irene Faust 2 , Brad A Racette 2, 3 , David B Clifford 2 , Harvey Checkoway 4, 5 , Susan Searles Nielsen 2
Affiliation  

INTRODUCTION Herpesviruses might play a role in the pathogenesis of neurodegenerative disorders. We sought to examine a possible association between alpha herpesvirus infections and Parkinson's disease. METHODS We conducted a population-based case-control study of incident Parkinson's disease in 2009 Medicare beneficiaries age 66-90 years (89,790 cases, 118,095 randomly selected comparable controls). We classified beneficiaries with any diagnosis code for "herpes simplex" and/or "herpes zoster" in the previous 5 years as having had the respective alpha herpesviruses. In beneficiaries with Part D prescription coverage, we also identified those prescribed anti-herpetic medications. We calculated odds ratios (OR) and 95% CI between alpha herpesvirus diagnosis/treatment and Parkinson's disease with logistic regression, with adjustment for age, sex, race/ethnicity, smoking, and use of medical care. RESULTS Parkinson's disease risk was inversely associated with herpes simplex (OR 0.79, 95% CI 0.74-0.84), herpes zoster (OR 0.88, 95% CI 0.85-0.91), and anti-herpetic medications (OR 0.87, 95% CI 0.80-0.96). CONCLUSION Herpesvirus infection or treatment might reduce risk of Parkinson's disease, but future studies will be required to explore whether this inverse association is causal.

中文翻译:

疱疹病毒感染和帕金森病的风险

引言 疱疹病毒可能在神经退行性疾病的发病机制中发挥作用。我们试图研究α疱疹病毒感染与帕金森病之间可能存在的关联。方法 我们对 2009 年 66-90 岁医疗保险受益人帕金森病事件进行了一项基于人群的病例对照研究(89,790 例,随机选择的 118,095 名对照)。我们将过去 5 年内具有任何“单纯疱疹”和/或“带状疱疹”诊断代码的受益人分类为患有相应的甲型疱疹病毒。在具有 D 部分处方保险的受益人中,我们还确定了那些处方的抗疱疹药物。我们通过逻辑回归计算了甲型疱疹病毒诊断/治疗与帕金森病之间的比值比 (OR) 和 95% CI,并对年龄、性别、种族/民族、吸烟和医疗护理的使用进行了调整。结果 帕金森病风险与单纯疱疹(OR 0.79,95% CI 0.74-0.84)、带状疱疹(OR 0.88,95% CI 0.85-0.91)和抗疱疹药物(OR 0.87,95% CI 0.80-0.80)呈负相关。 0.96)。结论 疱疹病毒感染或治疗可能会降低帕金森病的风险,但需要未来的研究来探讨这种负相关是否是因果关系。
更新日期:2020-01-01
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