Among the ~22,000 human genes, very few remain that have unknown functions. One such example is suprabasin (SBSN). Originally described as a component of the cornified envelope, the function of stratified epithelia-expressed SBSN is unknown. Both the lack of knowledge about the gene role under physiological conditions and the emerging link of SBSN to various human diseases, including cancer, attract research interest. The association of SBSN expression with poor prognosis of patients suffering from oesophageal carcinoma, glioblastoma multiforme, and myelodysplastic syndromes suggests that SBSN may play a role in human tumourigenesis. Three SBSN isoforms code for the secreted proteins with putative function as signalling molecules, yet with poorly described effects. In this first review about SBSN, we summarised the current knowledge accumulated since its original description, and we discuss the potential mechanisms and roles of SBSN in both physiology and pathology.

中文翻译：

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Suprabasin——回顾

在大约 22,000 个人类基因中，只有极少数具有未知功能。一个这样的例子是 suprabasin (SBSN)。最初被描述为角化包膜的一个组成部分，分层上皮表达的 SBSN 的功能是未知的。缺乏关于生理条件下基因作用的知识以及 SBSN 与各种人类疾病（包括癌症）的新兴联系，都引起了研究兴趣。SBSN 表达与食管癌、多形性胶质母细胞瘤和骨髓增生异常综合征患者预后不良的关联表明 SBSN 可能在人类肿瘤发生中发挥作用。三种 SBSN 同种型编码分泌蛋白，具有作为信号分子的假定功能，但效果不佳。在关于 SBSN 的第一篇评论中，