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Litter Size of Sheep (Ovis aries): Inbreeding Depression and Homozygous Regions
Genes ( IF 3.5 ) Pub Date : 2021-01-18 , DOI: 10.3390/genes12010109
Lin Tao 1 , Xiaoyun He 1 , Xiangyu Wang 1 , Ran Di 1 , Mingxing Chu 1
Affiliation  

Ovine litter size (LS) is an important trait showing variability within breeds. It remains largely unknown whether inbreeding depression on LS exists based on genomic homozygous regions, and whether the homozygous regions resulted from inbreeding are significantly associated with LS in sheep. We here reanalyze a set of single nucleotide polymorphism (SNP) chip of six breeds to characterize the patterns of runs of homozygosity (ROH), to evaluate inbreeding levels and inbreeding depressions on LS, and to identify candidate homozygous regions responsible for LS. Consequently, unique ROH patterns were observed among six sheep populations. Inbreeding depression on LS was only found in Hu sheep, where a significant reduction of 0.016, 0.02, and 0.02 per 1% elevated inbreeding FROH4–8, FROH > 8 and the total inbreeding measure was observed, respectively. Nine significantly homozygous regions were found for LS in Hu sheep, where some promising genes for LS possibly via regulation of the development of oocytes (NGF, AKT1, and SYCP1), fertilization (SPAG17, MORC1, TDRD9, ZFYVE21, ADGRB3, and CKB), embryo implantation (PPP1R13B, INF2, and VANGL1) and development (DPPA2, DPPA4, CDCA4, CSDE1, and ADSSL1), and reproductive health (NRG3, BAG5, CKB, and XRCC3) were identified. These results from the present study would provide insights into the genetic management and complementary understandings of LS in sheep.

中文翻译:

绵羊(Ovis aries)的产仔数:近交衰退和纯合区域

绵羊产仔数 (LS) 是一个重要的性状,显示品种内的变异性。基于基因组纯合区域是否存在近交抑制对 LS 的抑制,以及近交产生的纯合区域是否与绵羊的 LS 显着相关,这在很大程度上仍然未知。我们在这里重新分析了一组六个品种的单核苷酸多态性 (SNP) 芯片,以表征纯合性 (ROH) 运行模式,评估 LS 的近交水平和近交衰退,并确定负责 LS 的候选纯合区域。因此,在六个绵羊种群中观察到了独特的 ROH 模式。LS 的近交抑制仅在胡羊中发现,其中近交 FROH4-8、FROH > 8 和总近交测量每升高 1% 显着降低 0.016、0.02 和 0.02,分别。在胡羊中发现了 9 个 LS 的显着纯合区域,其中一些有希望的 LS 基因可能通过调节卵母细胞的发育(NGF、AKT1 和 SYCP1)、受精(SPAG17、MORC1、TDRD9、ZFYVE21、ADGRB3 和 CKB) 、胚胎植入(PPP1R13B、INF2 和 VANGL1)和发育(DPPA2、DPPA4、CDCA4、CSDE1 和 ADSSL1)以及生殖健康(NRG3、BAG5、CKB 和 XRCC3)。本研究的这些结果将为绵羊 LS 的遗传管理和补充理解提供见解。和 VANGL1)和发育(DPPA2、DPPA4、CDCA4、CSDE1 和 ADSSL1)和生殖健康(NRG3、BAG5、CKB 和 XRCC3)。本研究的这些结果将为绵羊 LS 的遗传管理和补充理解提供见解。和 VANGL1)和发育(DPPA2、DPPA4、CDCA4、CSDE1 和 ADSSL1)和生殖健康(NRG3、BAG5、CKB 和 XRCC3)。本研究的这些结果将为绵羊 LS 的遗传管理和补充理解提供见解。
更新日期:2021-01-18
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