Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent. Results provide proof of concept for personalized, circuit-specific medicine in psychiatry.

中文翻译：

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抑郁症患者对颅内脑刺激的状态依赖性反应

深部脑刺激是治疗严重抑郁症的一种有前途的治疗方法，但在随机试验中缺乏疗效引发了关于解剖靶向的问题。我们在一名严重抑郁的患者体内植入了多部位颅内电极，并系统地评估了对局灶性电神经调节的急性反应。我们发现了一系列独特的情绪反应，这些反应在开始时迅速、可重复，并且依赖于上下文和状态。结果为精神病学中个性化、特定回路的医学提供了概念证明。