Abstract

Two new isocoumarins penicimarins L-M (1–2), along with seven known analogues (3–9) were isolated from the mangrove-derived fungus Penicillium sp. MGP11. Compounds 1–2 were established by spectroscopic methods and comparison of their circular dichroism (CD) spectra with the literature. All isolated compounds were evaluated for antioxidant and α-glucosidase inhibitory activities. Compound 8 had better antioxidant activity (IC₅₀ = 4.6 μM) than positive control trolox (IC₅₀ = 12.9 μM). Compounds 5, 8 and 9 exhibited α-glucosidase inhibitory activity with the IC₅₀ values of 776.5, 683.7 and 868.7 μM, respectively.

摘要

两种新的异香豆素青霉素 LM ( 1-2 ) 以及七种已知的类似物 ( 3-9 ) 从红树林衍生的真菌青霉中分离出来。MGP11。化合物1-2是通过光谱方法确定的，并将它们的圆二色谱 (CD) 光谱与文献进行比较。评估所有分离的化合物的抗氧化和α-葡萄糖苷酶抑制活性。化合物8具有比阳性对照 trolox (IC ₅₀ = 12.9 μM)更好的抗氧化活性 (IC _{50 = 4.6 μM)。}化合物5、8和9表现出α-葡萄糖苷酶抑制活性，IC ₅₀值分别为 776.5、683.7 和 868.7 μM。