当前位置: X-MOL 学术Expert Opin. Drug Deliv. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Application of chloroquine as an endosomal escape enhancing agent: new frontiers for an old drug
Expert Opinion on Drug Delivery ( IF 6.6 ) Pub Date : 2021-01-22 , DOI: 10.1080/17425247.2021.1873272
Mohammad Hajimolaali 1 , Hosein Mohammadian 2 , Ali Torabi 2 , Amin Shirini 2 , Mostafa Khalife Shal 2 , Hami Barazandeh Nezhad 3 , Sheida Iranpour 2 , Reza Baradaran Eftekhari 2, 4 , Farid Dorkoosh 2, 4
Affiliation  

ABSTRACT

Introduction

Adequate transfection efficiency is indispensable to safe and effective delivery of therapeutically active agents, particularly in cancer. Endosomal escape is regarded as a critical and determining step devoted a significant number of studies of the drug/gene delivery field.

Areas covered

This paper critically reviews the fundamental properties of chloroquine (CQ), its pharmacokinetics, pharmacodynamics, and clinical applications and the present knowledge of CQ application as an endosomal escape enhancing agent. Different approaches to enhance the endosomal escape process of nanoparticles have been introduced including use of endosomal escape enhancing agents. Application of CQ as either a pre-treatment modality in which cells or animals are exposed to CQ prior to the main treatment or a component of co-delivery systems where CQ and other anti-cancer agents are simultaneously entered the cancer cells, is discussed with recent studies.

Expert opinion

CQ is founded to intervene with the natural process of endosomal maturation. Moreover, CQ seems to increase the effectiveness of gene delivery by its electrostatic interaction with negatively charged components of the transferred genetic molecules. Endosomal escape might be regarded as the bottleneck of efficient gene delivery and CQ as an effective and available endosomal escape enhancing agent deserves more sophisticated studies.



中文翻译:

氯喹作为内体逃逸增强剂的应用:老药的新领域

摘要

介绍

足够的转染效率对于安全有效地递送治疗活性剂是必不可少的,尤其是在癌症中。内体逃逸被认为是一个关键和决定性的步骤,致力于大量药物/基因传递领域的研究。

覆盖区域

本文批判性地回顾了氯喹 (CQ) 的基本特性、其药代动力学、药效学和临床应用,以及 CQ 作为内体逃逸增强剂的应用知识。已经引入了不同的方法来增强纳米粒子的内体逃逸过程,包括使用内体逃逸增强剂。CQ 作为一种预处理方式的应用,其中细胞或动物在主要治疗之前暴露于 CQ 或共同递送系统的一个组成部分,其中 CQ 和其他抗癌剂同时进入癌细胞,讨论了最近的研究。

专家意见

CQ 旨在干预内体成熟的自然过程。此外,CQ 似乎通过其与转移的遗传分子的带负电荷的成分的静电相互作用来提高基因传递的有效性。内体逃逸可能被视为有效基因传递的瓶颈,而 CQ 作为一种有效且可用的内体逃逸增强剂值得更深入的研究。

更新日期:2021-01-22
down
wechat
bug