During the global outbreak of COVID‐19 pandemic, “cytokine storm” conditions are regarded as the fatal step resulting in most mortality. Hemoperfusion is widely used to remove cytokines from the blood of severely ill patients to prevent uncontrolled inflammation induced by a cytokine storm. This article discoveres, for the first time, that 2D Ti₃C₂T_x MXene sheet demonstrates an ultrahigh removal capability for typical cytokine interleukin‐6. In particular, MXene shows a 13.4 times higher removal efficiency over traditional activated carbon absorbents. Molecular‐level investigations reveal that MXene exhibits a strong chemisorption mechanism for immobilizing cytokine interleukin‐6 molecules, which is different from activated carbon absorbents. MXene sheet also demonstrates excellent blood compatibility without any deleterious side influence on the composition of human blood. This work can open a new avenue to use MXene sheets as an ultraefficient hemoperfusion absorbent to eliminate the cytokine storm syndrome in treatment of severe COVID‐19 patients.

中文翻译：

---

使用 Ti3C2Tx MXene 超高效地平息细胞因子风暴

在COVID-19全球大流行期间，“细胞因子风暴”条件被认为是导致大多数死亡的致命步骤。血液灌流广泛用于去除重症患者血液中的细胞因子，以防止细胞因子风暴引起的不受控制的炎症。本文首次发现 2D Ti ₃ C ₂ T _x MXene 片材对典型细胞因子白介素-6 具有超高去除能力。特别是，MXene 的去除效率比传统活性炭吸收剂高 13.4 倍。分子水平研究表明，MXene 表现出强大的化学吸附机制，可固定细胞因子白细胞介素-6 分子，这与活性炭吸附剂不同。MXene 片材还表现出优异的血液相容性，不会对人体血液成分产生任何有害的副作用。这项工作可以开辟一条新途径，使用 MXene 片作为超高效血液灌流吸收剂来消除治疗重症 COVID-19 患者的细胞因子风暴综合征。