The skin is a unique immune organ that constitutes a complex network of physical, chemical and microbiological barriers against external insults. Keratinocytes are the most abundant cell type in the epidermis. These cells form the physical skin barrier and represent the first line of the host defense system by sensing pathogens via innate immune receptors, initiating anti‐microbial responses and producing various cytokines, chemokines and anti‐microbial peptides, which are important events in immunity. A damaged epidermal barrier in atopic dermatitis allows the penetration of potential allergens and pathogens to activate keratinocytes. Among the dysregulation of immune responses in atopic dermatitis, activated keratinocytes play a role in several biological processes that contribute to the pathogenesis of atopic dermatitis. In this review, we summarize the current understanding of the innate immune functions of keratinocytes in the pathogenesis of atopic dermatitis, with a special emphasis on skin‐derived anti‐microbial peptides and atopic dermatitis‐related cytokines and chemokines in keratinocytes. An improved understanding of the innate immunity mediated by keratinocytes can provide helpful insight into the pathophysiological processes of atopic dermatitis and support new therapeutic efforts.

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角质形成细胞：特应性皮炎中的先天免疫细胞

皮肤是一种独特的免疫器官，它构成了一个复杂的网络，由物理、化学和微生物屏障组成，可抵御外部损伤。角质形成细胞是表皮中最丰富的细胞类型。这些细胞形成物理皮肤屏障，代表宿主防御系统的第一道防线，通过先天免疫受体感知病原体、启动抗微生物反应并产生各种细胞因子、趋化因子和抗微生物肽，这些是免疫中的重要事件。特应性皮炎中受损的表皮屏障允许潜在的过敏原和病原体渗透以激活角质形成细胞。在特应性皮炎的免疫反应失调中，活化的角质形成细胞在导致特应性皮炎发病机制的几个生物学过程中发挥作用。在本次审查中，我们总结了目前对角质形成细胞在特应性皮炎发病机制中的先天免疫功能的认识，特别强调了皮肤衍生的抗菌肽和角质形成细胞中与特应性皮炎相关的细胞因子和趋化因子。更好地理解由角质形成细胞介导的先天免疫有助于深入了解特应性皮炎的病理生理过程并支持新的治疗工作。