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Alzheimer’s disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid
Metabolic Brain Disease ( IF 3.6 ) Pub Date : 2020-11-07 , DOI: 10.1007/s11011-020-00639-7
Tarek M Mohamed 1 , Menna Allah M Youssef 2 , Azza A Bakry 2 , Mai M El-Keiy 1
Affiliation  

The foremost neurodegenerative disease is Alzheimer’s (AD), which is characterized as a gradual decrease in memory, cognitive function, and also personal changes occurred. This study aims to assess the role of boswellic bioactive component in control Alzheimer’s disease through enhancing mitochondrial electron transport chain complexes in the rat model. Rats were divided into five equal groups: the control group (G1), boswellic acid control group (G2), AD disease group (G3), boswellic acid –pre-treated group (G4) and boswellic acid-treated group (G5). At the end of the experiment, blood glucose level, tau protein, different neurochemicals parameters (dopamine, acetylcholine), L-malondialdehyde (MDA) levels, and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities was determined. Also, GLUT2 and mitochondrial electron transport chain complexes were evaluated. As a result, an increase in hippocampus glucose, tau protein expression, MDA and GLUT2 in the AD group (G3) compared to control groups (G1 and G2) has been recorded. These parameters were declined after pre (G4) and treated (G5) by boswellic acid. The neurochemicals, antioxidants parameters, four mitochondrial chain complexes activities and their gene expression in the hippocampus of the AD group were decreased compared to the control groups (G1 and G2). In contrast, pre and treated groups by boswellic acid (G4 and G5, respectively) have shown an increase in antioxidants parameters, and the activities of four mitochondrial complexes, with the best improvement in the pre-treated group (G4), then treated group (G5). In conclusion; the boswellic acid improved the antioxidant and mitochondrial complexes in Alzheimer’s disease.



中文翻译:

乳香酸通过线粒体链复合物的活性及其在大鼠中的基因表达改善阿尔茨海默病

最重要的神经退行性疾病是阿尔茨海默氏症 (AD),其特点是记忆力、认知功能逐渐下降,个人也发生了变化。本研究旨在通过增强大鼠模型中的线粒体电子传递链复合物来评估乳香生物活性成分在控制阿尔茨海默病中的作用。将大鼠分为五个相等的组:对照组(G1)、乳香酸对照组(G2)、AD疾病组(G3)、乳香酸预处理组(G4)和乳香酸处理组(G5)。实验结束时,血糖水平、tau蛋白、不同神经化学参数(多巴胺、乙酰胆碱)、L-丙二醛(MDA)水平以及超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GPx)活性为决定。还,评估了 GLUT2 和线粒体电子传递链复合物。因此,与对照组(G1 和 G2)相比,AD 组(G3)中海马体葡萄糖、tau 蛋白表达、MDA 和 GLUT2 均有所增加。这些参数在预(G4)和乳香酸处理(G5)后下降。与对照组(G1 和 G2)相比,AD 组的神经化学物质、抗氧化剂参数、四种线粒体链复合物活性及其在海马中的基因表达降低。相比之下,乳香酸预处理组和处理组(分别为 G4 和 G5)的抗氧化剂参数和四种线粒体复合物的活性均有所增加,预处理组(G4)的改善最好,然后是处理组(G5)。综上所述;

更新日期:2020-11-07
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