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Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax)
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2021-01-01 , DOI: 10.1007/s10517-021-05072-z
M V Svishcheva 1 , Ye S Mishina 1 , O A Medvedeva 1 , I I Bobyntsev 1 , A Y Mukhina 1 , P V Kalutskii 1 , L A Andreeva 2 , N F Myasoedov 2
Affiliation  

We studied the effect of intraperitoneal administration ACTH(4-7)-PGP in doses of 5, 50, 150, and 450 μg/kg to Wistar male rats 12-15 min before modeling restraint stress on the morphofunctional state of the colon. In rats exposed to restraint stress, signs of atrophy and inflammatory reaction in the colon wall, changes in functional activity and number of mast cells, and increased serum level of corticosterone were observed. Administration of the peptide led to a decrease in corticosterone concentration, alleviated stress-induced pathomorphological changes, and promoted adaptation of the intestinal wall to stress. The positive effects of ACTH(4-7)-PGP can be determined by multifunctional nature of the physiological and pharmacological effects of the neuropeptide.

中文翻译:

抑制应激条件下大鼠大肠的形态功能状态和肽ACTH(4-7)-PGP (Semax)

我们研究了 5、50、150 和 450 μg/kg 剂量的 ACTH(4-7)-PGP 对 Wistar 雄性大鼠进行腹腔注射 12-15 分钟后对结肠形态功能状态的束缚应激模型的影响。在暴露于束缚应激的大鼠中,观察到结肠壁萎缩和炎症反应的迹象,功能活性和肥大细胞数量的变化,以及血清皮质酮水平升高。肽的给药导致皮质酮浓度降低,减轻应激引起的病理形态变化,并促进肠壁对应激的适应。ACTH(4-7)-PGP 的积极作用可以通过神经肽的生理和药理作用的多功能性质来确定。
更新日期:2021-01-01
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