Synbiotics synergistically favors beneficial effects of prebiotics and probiotics towards host metabolic health by modulating gut ecosystem. In this study, we sought to examine the effects of prebiotics (Schizophyllum commune derived β-(1,3/1,6)-glucan), probiotics (concoction made of eight different bacterial strains) and synbiotics (prebiotics + probiotics) on gut microbiota and its associated metabolic functions through 16S rRNA gene sequences analysis. Results showed that probiotics strains used in this study were detected more in the synbiotic and probiotic treatments, while prebiotic dietary intervention increased the total bacterial abundance and metabolisms related to host immune strengthening. Probiotics and synbiotics dietary interventions enhanced similar metabolisms relating to butanediol and s-adenosyl-l-methionine biosynthesis. Probiotics treatment also showed depleted metabolic activities related to SCFA productions, that were not depleted in prebiotics treatment. With varying differential abundance patterns and metabolic activities across the treatments, our results suggest that synbiotic treatment provide more beneficial effects over probiotics and prebiotics.

中文翻译：

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益生菌Schizophyllum commune衍生的β-（1,3 / 1,6）-葡聚糖与益生菌的合生素补充有益于肠道菌群及其相关的代谢活性

合生元通过调节肠道生态系统，协同促进益生元和益生菌对宿主代谢健康的有益作用。在这项研究中，我们试图检查益生元（Schizophyllum commune衍生的β-（1,3 / 1,6）-葡聚糖），益生菌（由八种不同细菌菌株制成的混合物）和合生素（益生菌+益生菌）对肠道的影响。通过16S rRNA基因序列分析发现微生物群及其相关的代谢功能。结果表明，本研究中使用的益生菌菌株在合生元和益生菌治疗中检出率更高，而益生元的饮食干预增加了与宿主免疫增强有关的总细菌丰度和代谢。益生菌和合生元饮食干预可增强与丁二醇和s-腺苷-1-蛋氨酸生物合成有关的相似代谢。益生菌治疗还显示出与SCFA产生有关的代谢活动减少，而益生菌治疗中并未耗尽。在整个治疗过程中，随着不同的丰度模式和代谢活动的变化，我们的结果表明，合生元治疗提供了比益生菌和益生元更有益的作用。