Trends in Biotechnology ( IF 17.3 ) Pub Date : 2021-01-16 , DOI: 10.1016/j.tibtech.2020.12.009 Julia Jodlbauer 1 , Thomas Rohr 1 , Oliver Spadiut 2 , Marko D Mihovilovic 1 , Florian Rudroff 1
Recently, several studies have proven the potential of cyanobacteria as whole-cell biocatalysts for biotransformation. Compared to heterotrophic hosts, cyanobacteria show unique advantages thanks to their photoautotrophic metabolism. Their ability to use light as energy and CO2 as carbon source promises a truly sustainable production platform. Their photoautotrophic metabolism offers an encouraging source of reducing power, which makes them attractive for redox-based biotechnological purposes. To exploit the full potential of these whole-cell biocatalysts, cyanobacterial cells must be considered in their entirety. With this emphasis, this review summarizes the latest developments in cyanobacteria research with a strong focus on the benefits associated with their unique metabolism. Remaining bottlenecks and recent strategies to overcome them are evaluated for their potential in future applications.
中文翻译:
绿色和蓝色的生物催化:蓝藻
最近,几项研究证明了蓝藻作为生物转化全细胞生物催化剂的潜力。与异养宿主相比,蓝藻由于其光合自养代谢而显示出独特的优势。他们利用光作为能量和 CO 2 的能力作为碳源承诺一个真正可持续的生产平台。它们的光合自养代谢提供了令人鼓舞的还原能力来源,这使它们对基于氧化还原的生物技术目的具有吸引力。为了充分发挥这些全细胞生物催化剂的潜力,必须全面考虑蓝藻细胞。以此为重点,本综述总结了蓝藻研究的最新进展,重点关注与其独特代谢相关的益处。评估剩余的瓶颈和最近克服它们的策略,以了解它们在未来应用中的潜力。