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Minimal effects from a single exposure to sevoflurane in adult male and female Sprague-Dawley rats
Neurotoxicology and Teratology ( IF 2.9 ) Pub Date : 2021-01-16 , DOI: 10.1016/j.ntt.2021.106955
Timothy J Flanigan 1 , Charles D Law 1 , Sherry A Ferguson 1
Affiliation  

Many people undergo procedures requiring general anesthesia each day and adverse cognitive effects have been reported in response to that anesthesia. Postoperative Cognitive Dysfunction (POCD) may occur in as many as 80% of adults during the first post-surgical week and can have lasting effects. Here, the cognitive and motor effects of sevoflurane exposure in Sprague-Dawley rats was examined along with body weights, blood oxygen saturation, heart rate, and body temperature. Male and female rats were exposed to 2.5% sevoflurane or medical grade air for one hour at postnatal day 115. Beginning the following day, rats began a series of behavioral tests examining locomotor activity, motor coordination, novel object recognition, and spatial learning and memory in a water maze. Blood oxygen saturation, heart rate, and body temperature were not affected by the sevoflurane exposure. A slight effect on locomotor activity was detected, but no effects on motor coordination, novel object recognition, or spatial learning and memory were observed. Brain weights following behavioral testing did not differ. The results reported here along with existing literature suggest sevoflurane is largely without effects on later cognition in adult rodents when exposure is of a relatively short duration and at a relatively low concentration.



中文翻译:

成年雄性和雌性 Sprague-Dawley 大鼠单次接触七氟醚的影响最小

许多人每天都接受需要全身麻醉的手术,并且已经报告了对这种麻醉的不良认知影响。在手术后的第一个星期内,多达 80% 的成年人可能会发生术后认知功能障碍 (POCD),并且会产生持久的影响。在这里,与体重、血氧饱和度、心率和体温一起检查了七氟醚暴露对 Sprague-Dawley 大鼠的认知和运动影响。在出生后第 115 天,雄性和雌性大鼠暴露于 2.5% 七氟醚或医用级空气中一小时。从第二天开始,大鼠开始进行一系列行为测试,检查运动活动、运动协调性、新物体识别以及空间学习和记忆在水迷宫中。血氧饱和度、心率、和体温不受七氟醚暴露的影响。检测到对运动活动的轻微影响,但没有观察到对运动协调、新物体识别或空间学习和记忆的影响。行为测试后的大脑重量没有差异。此处报告的结果以及现有文献表明,当暴露时间相对较短且浓度相对较低时,七氟醚对成年啮齿动物的后期认知基本上没有影响。

更新日期:2021-01-24
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