Journal of Comparative Pathology ( IF 0.8 ) Pub Date : 2021-01-16 , DOI: 10.1016/j.jcpa.2020.12.001 Stephanie M Mota 1 , Mark F Stidworthy 2 , Amanda Guthrie 3 , Simon Spiro 3 , Daniela Denk 2
Cryptococcosis is widely reported in North America and Australia but considered rare in the UK. Disease is mainly caused by Cryptococcus neoformans and Cryptococcus gattii and affects animals and humans. Cases of cryptococcosis have been described in non-human primates, including a few in the Callitrichidae family. Six captive callitrichids from five zoological facilities in the UK were diagnosed with cryptococcosis on post-mortem examination over a 13-year period. Histological examination revealed intralesional yeast bodies consistent with Cryptococcus spp in lung, brain, lymph nodes, larynx, salivary gland and ears. C. neoformans was confirmed in two cases by culture and by culture and polymerase chain reaction (28S rRNA gene), respectively. This case series is the first report of Cryptococcus spp in captive callitrichids in the UK and reinforces the need to include this fungal disease in the differential diagnosis of sick callitrichids in zoo settings.
中文翻译:
英国圈养 Callitrichids 中的隐球菌感染
隐球菌病在北美和澳大利亚被广泛报道,但在英国被认为很少见。疾病主要由新型隐球菌和格氏隐球菌引起,影响动物和人类。已经在非人类灵长类动物中描述了隐球菌病病例,包括一些 Callitrichidae 家族。在 13 年的时间里,来自英国 5 个动物园的 6 只圈养 callitrichids 在尸检中被诊断出患有隐球菌病。组织学检查显示病灶内酵母体与肺、脑、淋巴结、喉、唾液腺和耳朵中的隐球菌一致。隐球菌分别通过培养和培养和聚合酶链反应(28S rRNA 基因)证实了两种情况。该病例系列是英国圈养 callitrichids 中隐球菌属的第一份报告,并强调了将这种真菌疾病纳入动物园环境中患病 callitrichids 鉴别诊断的必要性。