当前位置: X-MOL 学术Brain Dev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Low-dose phenobarbital for epilepsy with myoclonic absences: A case report
Brain and Development ( IF 1.7 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.braindev.2020.12.018
Susumu Ito 1 , Kaoruko Nagumo 1 , Aiko Nishikawa 1 , Hirokazu Oguni 1 , Satoru Nagata 1
Affiliation  

BACKGROUND Epilepsy with myoclonic absences (EMA) is a rare childhood-onset syndrome characterized by absences of responsiveness accompanied by bilateral rhythmic clonic-like myoclonic jerks. Herein, we describe the case of a child with EMA, resistant to multiple commonly used antiepileptic drugs, in whom low-dose phenobarbital unexpectedly achieved complete remission of epilepsy. CASE REPORT A 10-year-old boy was referred to our hospital because of pharmaco-resistant frequent myoclonic absence seizures (MASs) and occasional generalized tonic-clonic seizures (GTCSs) that had commenced at the age of 7 years. Antiepileptic drugs including valproate sodium (VPA), levetiracetam, ethosuximide (ESM), clobazam, zonisamide, topiramate, clonazepam and lamotrigine were tested without significant effects. At the age of 8 years, phenobarbital was added to the VPA and ESM and increased to 1.2 mg/kg/day (blood concentration 8.6 µg/mL), which suppressed MASs completely within 1 month, and epileptic discharges on electroencephalography (EEG) within 5 months. To date, the boy has been seizure-free with normal EEG for 2 years. CONCLUSION Phenobarbital is a potential therapeutic option for pharmaco-resistant EMA.

中文翻译:

低剂量苯巴比妥治疗伴肌阵挛性癫痫的病例报告

背景 伴有肌阵挛的癫痫 (EMA) 是一种罕见的儿童期发病综合征,其特征是缺乏反应并伴有双侧节律性阵挛样肌阵挛抽搐。在此,我们描述了一名患有 EMA 的儿童,对多种常用的抗癫痫药物耐药,其中低剂量苯巴比妥意外地实现了癫痫的完全缓解。病例报告 一名 10 岁男孩因药物耐药性频繁肌阵挛失神发作 (MAS) 和偶发的全身性强直阵挛发作 (GTCS) 而被转诊到我院,这些发作始于 7 岁。抗癫痫药物包括丙戊酸钠 (VPA)、左乙拉西坦、乙琥胺 (ESM)、氯巴占、唑尼沙胺、托吡酯、氯硝西泮和拉莫三嗪,经测试均无显着影响。在 8 岁的时候,在 VPA 和 ESM 中加入苯巴比妥并增加到 1.2 mg/kg/天(血浓度 8.6 µg/mL),在 1 个月内完全抑制 MAS,在 5 个月内抑制脑电图(EEG)上的癫痫放电。迄今为止,该男孩已无癫痫发作,脑电图正常 2 年。结论 苯巴比妥是耐药性 EMA 的潜在治疗选择。
更新日期:2021-01-01
down
wechat
bug