Hundreds of genes interact with the yeast nuclear pore complex (NPC), localizing at the nuclear periphery and clustering with co-regulated genes. Dynamic tracking of peripheral genes shows that they cycle on and off the NPC and that interaction with the NPC slows their sub-diffusive movement. Furthermore, NPC-dependent inter-chromosomal clustering leads to coordinated movement of pairs of loci separated by hundreds of nanometers. We developed Fractional Brownian Motion simulations for chromosomal loci in the nucleoplasm and interacting with NPCs. These simulations predict the rate and nature of random sub-diffusion during repositioning from nucleoplasm to periphery and match measurements from two different experimental models, arguing that recruitment to the nuclear periphery is due to random subdiffusion, collision, and capture by NPCs. Finally, the simulations do not lead to interchromosomal clustering or coordinated movement, suggesting that interaction with the NPC is necessary, but not sufficient, to cause clustering.

中文翻译：

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核孔的随机亚扩散和基因捕获减少了动力学并协调了染色体间的运动

数百个基因与酵母核孔复合物（NPC）相互作用，位于核外围并与共同调控的基因成簇。对周围基因的动态跟踪表明，它们在NPC上上下循环，并且与NPC的相互作用减慢了其亚扩散运动。此外，依赖NPC的染色体间聚类导致成对的基因座相互协调运动，这些基因座之间相隔数百纳米。我们针对核质中的染色体基因座并与NPC相互作用开发了分数布朗运动模拟。这些模拟预测了从核质向外围重新定位期间随机亚扩散的速率和性质，并匹配了两个不同实验模型的测量结果，认为向核外围的募集是由于NPC的随机亚扩散，碰撞和捕获。最后，