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Adiponectin Preserves Metabolic Fitness During Aging
bioRxiv - Cell Biology Pub Date : 2021-01-15 , DOI: 10.1101/2021.01.14.426678
Na Li , Zhuzhen Zhang , Shangang Zhao , Yi Zhu , Christy M. Gliniak , Lavanya Vishvanath , Yu A. An , May-yun Wang , Yingfeng Deng , Qingzhang Zhu , Toshiharu Onodera , Orhan K Oz , Ruth Gordillo , Rana K. Gupta , Ming Liu , Tamas L. Horvath , Vishwa Deep Dixit , Philipp E. Scherer

Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet (HFD). In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.

中文翻译:

脂联素在衰老过程中保持代谢适应性

脂联素对于调节组织底物利用率和全身性胰岛素敏感性至关重要。临床研究表明循环脂联素与健康寿命和寿命呈正相关。然而,脂联素对促进健康和寿命的直接作用尚待探索。在这里,我们使用的是脂联素无效小鼠和转基因脂联素过表达模型。我们直接评估循环脂联素对衰老过程的影响,发现脂联素缺失小鼠表现出与年龄有关的糖和脂质代谢紊乱加剧。此外,脂联素缺失小鼠在食物和高脂饮食(HFD)上的寿命均明显缩短。相比之下,循环脂联素水平升高的转基因小鼠模型具有显着改善的全身胰岛素敏感性,减少了与年龄有关的组织炎症和纤维化,并延长了健康寿命和中位寿命。这些结果支持脂联素作为健康寿命和寿命的重要调节剂的作用。
更新日期:2021-01-18
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