Bacteria of the genus Xanthomonas cause a wide variety of economically important diseases in most crops. The virulence of the majority of Xanthomonas spp. is dependent on secretion and translocation of effectors by the type 3 secretion system (T3SS) that is controlled by two master transcriptional regulators HrpG and HrpX. Since their discovery in the 1990s, the two regulators were the focal point of many studies aiming to decipher the regulatory network that controls pathogenicity in Xanthomonas bacteria. HrpG controls the expression of HrpX, which subsequently controls the expression of T3SS apparatus genes and effectors. The HrpG/HrpX regulon is activated in planta and subjected to tight metabolic and genetic regulation. In this review, we cover the advances made in understanding the regulatory networks that control and are controlled by the HrpG/HrpX regulon and their conservation between different Xanthomonas spp.

中文翻译：

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Xanthomonads的HrpG / HrpX调节子-对致病细菌致病性状调控的复杂性的认识。

黄单胞菌属细菌在大多数农作物中引起多种经济上重要的疾病。Xanthomonas spp的大多数的毒力。依赖于由两个主转录调节因子HrpG和HrpX控制的3型分泌系统（T3SS）的效应子的分泌和转运。自1990年代发现以来，这两种调节剂一直是许多研究的重点，旨在破译控制Xanthomonas细菌致病性的调节网络。HrpG控制HrpX的表达，HrpX随后控制T3SS装置基因和效应子的表达。HrpG / HrpX调节剂已在植物中激活并受到严格的代谢和遗传调控。在这篇综述中，我们介绍了在了解控制HrpG / HrpX调控因子并受其调控的调控网络及其在不同黄单胞菌属之间的保守性方面的进展。