The role of autophagy is to degrade damaged or unnecessary cellular structures. Both in vivo and in vitro studies suggest a dual role of autophagy in cancer—it may promote the development of neoplasms, but it may also play a tumor protective function. The mechanism of autophagy depends on the genetic context, tumor stage and type, tumor microenvironment, or clinical therapy used. Autophagy also plays an important role in cell death as well as in the induction of chemoresistance of cancer cells. The following review describes the extensive autophagic cell death in relation to dietary polyphenols and cancer disease. The review documents increasing use of polyphenolic compounds in cancer prevention, or as agents supporting oncological treatment. Polyphenols are organic chemicals that exhibit antioxidant, anti-inflammatory, anti-angiogenic, and immunomodulating properties, and can also initiate the process of apoptosis. In addition, polyphenols reduce oxidative stress and protect against reactive oxygen species. This review presents in vitro and in vivo studies in animal models with the use of polyphenolic compounds such as epigallocatechin-3-gallate (EGCG), oleuropein, punicalgin, apigenin, resveratrol, pterostilbene, or curcumin and their importance in the modulation of autophagy-induced death of cancer cells.

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饮食中多酚对癌细胞自噬的调节

自噬的作用是降解受损或不必要的细胞结构。体内和体外研究均表明自噬在癌症中具有双重作用-它可能促进肿瘤的发展，但也可能发挥肿瘤保护功能。自噬的机制取决于遗传背景，肿瘤分期和类型，肿瘤微环境或所用的临床疗法。自噬在细胞死亡以及诱导癌细胞的化学抗性中也起重要作用。以下评论描述了与饮食多酚和癌症疾病相关的广泛自噬细胞死亡。该综述记录了多酚化合物在癌症预防中或作为支持肿瘤治疗的药物的越来越多的使用。多酚是具有抗氧化剂，抗炎，抗血管生成，和免疫调节特性，还可以启动细胞凋亡过程。此外，多酚可减少氧化应激并保护其免受活性氧的影响。这篇综述介绍了动物模型中的体外和体内研究，以及使用多酚化合物（例如表没食子儿茶素-3-没食子酸酯（EGCG），橄榄苦苷，punicalgin，芹菜素，白藜芦醇，紫檀皮或姜黄素的研究及其在调节自噬中的重要性。诱导癌细胞死亡。