Ochratoxin A (OTA) is a powerful mycotoxin found in various foods and feedstuff, responsible for subchronic and chronic toxicity, such as nephrotoxicity, hepatotoxicity, teratogenicity, and immunotoxicity to both humans and several animal species. The severity of the liver damage caused depends on both dose and duration of exposure. Several studies have suggested that oxidative stress might contribute to increasing the hepatotoxicity of OTA, and several antioxidants, including curcumin (CURC), have been tested to counteract the toxic hepatic action of OTA in various classes of animals. Therefore, the present study was designed to evaluate the protective effect of CURC, a bioactive compound with different therapeutic properties on hepatic injuries caused by OTA in rat animal models. CURC effects were examined in Sprague Dawley rats treated with CURC (100 mg/kg), alone or in combination with OTA (0.5 mg/kg), by gavage daily for 14 days. At the end of the experiment, rats treated with OTA showed alterations in biochemical parameters and oxidative stress in the liver. CURC dosing significantly attenuated oxidative stress and lipid peroxidation versus the OTA group. Furthermore, liver histological tests showed that CURC reduced the multifocal lymphoplasmacellular hepatitis, the periportal fibrosis, and the necrosis observed in the OTA group. This study provides evidence that CURC can preserve OTA-induced oxidative damage in the liver of rats.

中文翻译：

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姜黄素对O曲毒素A诱导的肝毒性的抗氧化作用

ch曲霉毒素A（OTA）是一种强大的霉菌毒素，存在于各种食品和饲料中，对亚慢性和慢性毒性负责，例如对人类和几种动物的肾毒性，肝毒性，致畸性和免疫毒性。造成的肝损害的严重程度取决于剂量和暴露时间。多项研究表明，氧化应激可能有助于增加OTA的肝毒性，并且已经测试了包括姜黄素（CURC）在内的几种抗氧化剂，以抵消OTA在各种动物中的毒性肝作用。因此，本研究旨在评估CURC（一种具有不同治疗特性的生物活性化合物）对大鼠动物模型中OTA引起的肝损伤的保护作用。在单独或与OTA（0.5 mg / kg）联合使用CURC（100 mg / kg）治疗的Sprague Dawley大鼠中，每天灌胃14天，检查其CURC效果。实验结束时，接受OTA处理的大鼠肝脏的生化参数和氧化应激发生改变。与OTA组相比，CURC剂量显着减轻了氧化应激和脂质过氧化作用。此外，肝组织学检查显示，CURC减少了在OTA组中观察到的多灶性淋巴浆细胞性肝炎，门静脉纤维化和坏死。这项研究提供了证据，表明CURC可以保留OTA诱导的大鼠肝脏氧化损伤。用OTA处理的大鼠肝脏中的生化参数和氧化应激发生改变。与OTA组相比，CURC剂量显着减轻了氧化应激和脂质过氧化作用。此外，肝组织学检查显示，CURC减少了在OTA组中观察到的多灶性淋巴浆细胞性肝炎，门静脉纤维化和坏死。这项研究提供了证据，表明CURC可以保留OTA诱导的大鼠肝脏氧化损伤。用OTA处理的大鼠肝脏中的生化参数和氧化应激发生改变。与OTA组相比，CURC剂量显着减轻了氧化应激和脂质过氧化作用。此外，肝组织学检查显示，CURC减少了在OTA组中观察到的多灶性淋巴浆细胞性肝炎，门静脉纤维化和坏死。这项研究提供了证据，表明CURC可以保留OTA诱导的大鼠肝脏氧化损伤。