High‐density lipoprotein cholesterol (HDL‐C) is negatively correlated with atherosclerotic cardiovascular disease. The prevalence of hypo‐HDL cholesterolemia is as high as 33.9%. The plasma metabolomic differences between hypo‐HDL cholesterolemia populations and normal controls were investigated using ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry. Participants with hypo‐HDL cholesterolemia and normal controls were clearly discriminated from each other on the orthogonal partial least squares–discriminant analysis score plot and a total of 90 differential metabolites were identified, including down‐regulated phosphatidylserine [18:0/20:3(8Z,11Z,14Z)], phosphatidylcholine [19:0/18:3(6Z,9Z,12Z)], phosphatidylserine, phosphatidylethanolamine [18:0/20:4(5Z,8Z,11Z,13E) (15Ke)], etc., and up‐regulated triglyceride [15:0/18:1(9Z)/18:3(9Z,12Z,15Z)][iso6], 13‐methyl‐1‐tritriacontene, tridodecylamine, etc. Most of the changed metabolites were lipids, notably, a significant part of which were odd chain fatty acid incorporated lipids. Carnitine shuttle was the most significant metabolic pathway, except for the disturbed glycerophospholipid metabolism, glycosphingolipid metabolism and sphingolipid metabolism in participants with hypo‐HDL cholesterolemia. We identified the key metabolites and metabolic pathways that may be changed in hypo‐HDL cholesterolemia participants, providing useful clues for studying the metabolic mechanisms and for early prevention of hypo‐HDL cholesterolemia and dyslipidemia.

中文翻译：

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通过UPLC-QTOF MS对正常体重低HDL胆固醇血症成年人的血浆进行代谢组学分析

高密度脂蛋白胆固醇（HDL-C）与动脉粥样硬化性心血管疾病呈负相关。低密度脂蛋白胆固醇血症的患病率高达33.9％。使用超高效液相色谱-四极杆飞行时间质谱法研究了低HDL胆固醇血症人群与正常对照组之间的血浆代谢组学差异。在正交偏最小二乘判别分析评分图上，HDL胆固醇水平低的参与者与正常对照组之间存在明显区别，共鉴定出90种差异代谢物，包括下调的磷脂酰丝氨酸[18：0/20：3（ 8 Z，11 Z，14 Z）]，磷脂酰胆碱[19：0/18：3（6 Z，9Z，12 Z）]，磷脂酰丝氨酸，磷脂酰乙醇胺[18：0/20：4（5 Z，8 Z，11 Z，13 E）（15Ke）]等，以及上调的甘油三酸酯[15：0/18 ：1（9 Z）/ 18：3（9 Z，12 Z，15 Z）] [iso6]，13-甲基-1-三triacontene，十三烷基胺等。大多数变化的代谢物是脂质，尤其是其中很大一部分是掺有奇链脂肪酸的脂质。肉碱穿梭是最重要的代谢途径，但低HDL胆固醇血症参与者的甘油磷脂代谢，糖鞘脂代谢和鞘脂代谢受到干扰。我们确定了低HDL胆固醇血症参与者中可能改变的关键代谢物和代谢途径，为研究代谢机制以及早期预防低HDL胆固醇血症和血脂异常提供了有用的线索。