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Roles of microRNAs in chronic pediatric diseases and their use as potential biomarkers: A review
Archives of Biochemistry and Biophysics ( IF 3.9 ) Pub Date : 2021-01-16 , DOI: 10.1016/j.abb.2021.108763
Sujay Paul , Luis M. Ruiz-Manriquez , S. Janin Ledesma-Pacheco , Javier A. Benavides-Aguilar , Andrea Torres-Copado , Jonathan I. Morales-Rodríguez , Marcos De Donato , Aashish Srivastava

MicroRNAs (miRNAs) are small non-coding highly conserved RNA molecules that can act as master regulators of gene expression in a sequence-specific manner either by translation repression or mRNA degradation, influencing a wide range of biologic processes that are essential for the maintenance of cellular homeostasis. Chronic pediatric diseases are the leading cause of death worldwide among children and the recent evidence indicates that aberrant miRNA expression significantly contributes to the development of chronic pediatric diseases. This review focuses on the role of miRNAs in five major chronic pediatric diseases including bronchial asthma, congenital heart diseases, cystic fibrosis, type 1 diabetes mellitus, and epilepsy, and their potential use as novel biomarkers for the diagnosis and prognosis of these disorders.



中文翻译:

microRNA在慢性儿科疾病中的作用及其作为潜在生物标志物的用途:综述

MicroRNA(miRNA)是小的非编码高度保守的RNA分子,可以通过翻译抑制或mRNA降解以序列特异性的方式充当基因表达的主要调控因子,影响广泛的生物学过程,这些过程对于维持MRNA至关重要细胞稳态。慢性儿科疾病是全世界儿童死亡的主要原因,最近的证据表明,miRNA的异常表达显着促进了慢性儿科疾病的发展。这篇综述着重于miRNA在五种主要的慢性儿科疾病中的作用,包括支气管哮喘,先天性心脏病,囊性纤维化,1型糖尿病和癫痫,以及它们在这些疾病的诊断和预后中作为新型生物标志物的潜在用途。

更新日期:2021-01-19
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