Dispersive liquid–liquid microextraction, based on ionic liquids for pioglitazone extraction in drug samples using high-efficiency liquid chromatography, was successful. In the present study, three-phase solvent system of water–acetone-ionic liquid 1-ethyl-3-methylimidazolium hexafluorophosphate (as an extracting solvent) was used as a suitable system for pioglitazone extraction and the parameters affecting the extraction efficiency as a variable in time were optimized. In this method, the value of the dynamic linear range of 0.05–1.5 µg mL⁻¹ for this compound was obtained. The repeatability of the method for 5 extractions and measurements at 1 ppm concentration of this compound was obtained based on the relative standard deviation of 4.6% (% RSD) for the sub-peak level as well as the limit of detection of 0.01 µg mL⁻¹. And the recycling rate is 96–98%, which shows the good accuracy of the method.

基于离子液体的高效液相色谱法提取离子液体的吡格列酮的分散液-液微萃取技术是成功的。在本研究中，水-丙酮离子液体六乙基磷酸1-乙基-3-甲基咪唑鎓六氟磷酸的三相溶剂体系（作为萃取溶剂）被用作吡格列酮的合适萃取系统，并且影响萃取效率的参数是一个变量。在时间上进行了优化。在这种方法中，动态线性范围的值为0.05–1.5 µg mL ^-1得到该化合物。基于针对所述子峰值电平，以及作为检测的0.01微克毫升的极限值的4.6％（％RSD）的相对标准偏差，获得5点提取和测量在该化合物的1个ppm的浓度的方法的可重复性^{- 1}。回收率为96–98％，表明该方法具有良好的准确性。