Uncoupling of respiration and ATP production by myocardial mitochondria was observed in rats with chronic isoproterenol intoxication (L-isoproterenol subcutaneously, 1 mg/kg, for 10 days) in comparison with controls (injected with the solvent). Inhibitors of NHE-1 zoniporide (1 mg/kg intraperitoneally, 13 days) and BMA-1321 compound (0.92 mg/kg intraperitoneally, 13 days) improved the mitochondrial function in rats with isoproterenol-induced cardiac failure: respiratory control coefficients increased, more so for the respiratory chain complex II, the main source of ROS in heart failure. The effect of BMA-1321 was more manifest (53%; p <0.05) in comparison with zoniporide (35%; p <0.05).

中文翻译：

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唑尼泊利特和BMA-1321化合物对实验性慢性心力衰竭大鼠心肌细胞线粒体吸氧率的影响

与对照组（注射溶剂）相比，在慢性异丙肾上腺素中毒（皮下注射 L-异丙肾上腺素，1 mg/kg，持续 10 天）的大鼠中观察到心肌线粒体的呼吸和 ATP 产生解偶联。NHE-1 唑尼泊利（1 mg/kg 腹腔注射，13 天）和 BMA-1321 化合物（0.92 mg/kg 腹腔注射，13 天）的抑制剂改善了异丙肾上腺素诱导的心力衰竭大鼠的线粒体功能：呼吸控制系数增加，更多因此对于呼吸链复合物 II，心力衰竭中 ROS 的主要来源。与唑尼泊利 (35%；p <0.05) 相比，BMA-1321 的作用更明显 (53%；p <0.05)。