We studied changes in LPO processes and antioxidant protection system in women with ovarian hyperandrogenism at various periods of reproductive age 18-45 years. An age-related decrease in total antioxidant activity and accumulation of secondary LPO products, ketodiens and coupled trienes, were found; these changes were accompanied by an increase in the level of superoxide dismutase and a decrease in the concentrations of reduced glutathione, α-tocopherol, and retinol. Women of early reproductive age (18-35 years) with hyperandrogenism were characterized by increased content of oxidized glutathione accompanied by a decrease in the level of α-tocopherol and retinol in comparison with the control group. In women of late reproductive age (35-45 years) with hyperandrogenism, increased superoxide dismutase activity in comparison with the control group was revealed.

中文翻译：

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不同生育年龄卵巢雄激素过多症女性脂质过氧化-抗氧化保护系统的变化

我们研究了 18-45 岁育龄期卵巢雄激素过多症女性 LPO 过程和抗氧化保护系统的变化。发现总抗氧化活性和次级 LPO 产物、酮二烯和偶联三烯的积累与年龄有关；这些变化伴随着超氧化物歧化酶水平的增加和还原型谷胱甘肽、α-生育酚和视黄醇浓度的降低。与对照组相比，患有雄激素过多症的育龄早期（18-35 岁）女性的特征是氧化型谷胱甘肽含量增加，同时α-生育酚和视黄醇水平降低。在具有高雄激素血症的育龄晚期（35-45 岁）女性中，