The mechanisms underlying cardioprotective activity of compound ALM-802 were studied in experiments on rats with chronic post-infarction heart failure. Real-time PCR showed that compound ALM-802 (daily intraperitoneal injections in a dose of 2 mg/kg for 28 days starting from day 91 after myocardial infarction modeling) restored the expression of genes encoding β1- ( p =0.00001) and β2-adrenoreceptors ( p =0.01) and type 2 ryanodine receptors ( p =0.008) in the myocardium that was reduced in control animals. These effects can serve as the basis for the ability of the compound to reduce the intensity of remodeling and increase the inotropic function of the left heart ventricle shown earlier in this model.

中文翻译：

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ALM-802 化合物心脏保护作用的分子机制研究

在慢性梗死后心力衰竭大鼠的实验中研究了化合物 ALM-802 心脏保护活性的潜在机制。实时 PCR 显示化合物 ALM-802（从心肌梗塞建模后第 91 天开始，每天以 2 mg/kg 的剂量腹腔注射，持续 28 天）恢复了编码 β1- (p = 0.00001) 和 β2- 的基因的表达心肌中的肾上腺素受体 (p = 0.01) 和 2 型兰尼碱受体 (p = 0.008) 在对照动物中减少。这些作用可以作为化合物降低重塑强度和增加该模型前面显示的左心室收缩功能的能力的基础。