Flucloxacillin is commonly administered intravenously for perioperative antimicrobial prophylaxis, while oral administration is typical for prophylaxis following smaller traumatic wounds. We assessed the time, for which the free flucloxacillin concentration was maintained above the minimum inhibitory concentration (fT > MIC) for methicillin-susceptible Staphylococcus aureus in soft and bone tissue, after intravenous and oral administration, using microdialysis in a porcine model.

中文翻译：

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静脉和口服给药后，通过微透析评估猪体内氟氯西林的骨和软组织浓度。

氟氯西林通常是静脉内给药，用于围手术期抗菌药物的预防，而口服通常用于较小创伤后的预防。我们评估了在猪模型中使用微透析静脉和口服给药后，游离氟氯西林浓度保持在软和骨组织中对甲氧西林敏感的金黄色葡萄球菌的最小抑制浓度（f T> MIC）以上的时间。