当前位置: X-MOL 学术Mini-Rev. Med. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Chemistry of Triazine Isomers: Structures, Reactions, Synthesis and Applications
Mini-Reviews in Medicinal Chemistry ( IF 3.8 ) Pub Date : 2020-11-30 , DOI: 10.2174/1389557520666200729160720
Neelottama Kushwaha 1 , C S Sharma 2
Affiliation  

Triazine is the six-membered heterocyclic ring containing three nitrogens, which replace the carbon-hydrogen unit in the benzene ring. Based on nitrogen position present in the ring system, it is categorized in three isomeric forms, i.e., 1, 2, 3-triazine (vicinal triazine), 1, 2, 4-triazine (asymmetrical triazine or isotriazine) and 1, 3, 5-triazine (symmetrical or s-triazine or cyanidine). Triazines have a weakly basic property. Their isomers have much weaker resonance energy than benzene structure, so nucleophilic substitution reactions are more preferred than electrophilic substitution reactions. Triazine isomers and their derivatives are known to play important roles possessing various activities in medicinal and agricultural fields such as anti-cancer, antiviral, fungicidal, insecticidal, bactericidal, herbicidal, antimalarial and antimicrobial agents.



中文翻译:

三嗪异构体的化学:结构,反应,合成和应用

三嗪是含有三个氮的六元杂环,可取代苯环中的碳氢单元。根据环系统中存在的氮位置,将其分为三种异构形式,即1,2,3-三嗪(邻位三嗪),1,2,4-三嗪(不对称三嗪或异三嗪)和1,3, 5-三嗪(对称或S-三嗪或氰基)。三嗪具有弱碱性。它们的异构体具有比苯结构弱得多的共振能,因此亲核取代反应比亲电子取代反应更优选。众所周知,三嗪异构体及其衍生物在医药和农业领域发挥着重要作用,具有多种活性,例如抗癌,抗病毒,杀真菌,杀虫,杀菌,除草,

更新日期:2021-01-15
down
wechat
bug