Background: Alzheimer's disease (AD) is one of the worst neurodegenerative disorders worldwide, with extracellular senile plaques (SP), subsequent intracellular neurofibrillary tangles (NFTs) and final neuron loss and synaptic dysfunction as the main pathological characteristics. Excessive apoptosis is the main cause of irreversible neuron loss. Thus, therapeutic intervention for these pathological features has been considered a promising strategy to treat or prevent AD. Dihydroartemisin (DHA) is a widely used first-line drug for malaria. Our previous study showed that DHA treatment significantly accelerated Aβ clearance, improved memory and cognitive deficits in vivo and restored autophagic flux both in vivo and in vitro.

背景：阿尔茨海默病（AD）是世界范围内最严重的神经退行性疾病之一，以细胞外老年斑（SP）、随后的细胞内神经原纤维缠结（NFT）和最终神经元丢失和突触功能障碍为主要病理特征。过度的细胞凋亡是造成不可逆神经元丢失的主要原因。因此，针对这些病理特征的治疗干预被认为是治疗或预防 AD 的一种有前景的策略。双氢青蒿素（DHA）是一种广泛使用的治疗疟疾的一线药物。我们之前的研究表明，DHA 治疗显着加速了 Aβ 清除，改善了体内记忆和认知缺陷，并恢复了体内和体外的自噬通量。