A Ru(II)-catalyzed facile and controllable protocol for C–H alkylation and spirocyclization of 2-arylquinoxalines with maleimides has been achieved under ambient air in high yields. Sequential ortho-C–H activation and C-annulation results in the formation of diverse polyheterocycles containing spiro[indeno[1,2-b]quinoxaline-11,3′-pyrrolidine]-2′,5′-diones, which are of potent interest in medicinal chemistry. Mechanistic investigations suggest a reversible cleavage of the ortho-C–H bond in the turnover-limiting step.

中文翻译：

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Ru（II）催化的可交换C–H烷基化和通过芳基C–H活化的马来酰亚胺与2-芳基喹喔啉的螺环化

在环境空气中以高收率获得了Ru（II）催化的CH-H烷基化和2-芳基喹喔啉与马来酰亚胺螺环化的简便且可控的方案。连续的邻-C-H活化和C-环化导致形成包含螺[茚并[1,2 - b ]喹喔啉-11,3'-吡咯烷] -2'，5'-二酮的多种多杂环对药物化学的浓厚兴趣。机理研究表明，在营业额限制步骤中邻-C-H键可逆裂解。