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Sleep disorders predict the one-year onset, persistence, but not remission of psychotic experiences in pre-adolescence: a longitudinal analysis of the ABCD cohort data
medRxiv - Psychiatry and Clinical Psychology Pub Date : 2021-09-07 , DOI: 10.1101/2021.01.15.21249864
Sarah Reeve , Vaughan Bell

The relationship between sleep disorder and psychotic experiences in preadolescence has not been extensively studied despite the potential for intervention. The current study addresses this relationship using the Adolescent Brain Cognitive Development (ABCD) cohort, which provides baseline data from 11,830 10 to 11-year-olds; for 4910 of these 1-year follow-up data is also available. A set of pre-registered multi-level regression models were applied to test whether a) sleep disorder is associated with psychotic experiences at baseline; b) baseline sleep disorder predicts psychotic experiences at follow-up; c) the persistence of sleep disorder predicts persistence of psychotic experiences at follow-up; d) the remission of sleep disorder predicts the remission of psychotic experiences at follow-up. After controlling for potential confounders, sleep disorder was associated with psychotic experiences cross-sectionally (OR=1.40, 95% CI 1.20-1.63), at one-year follow-up (OR=1.32, 95% CI 1.11-1.57), and the persistence of sleep disorder predicted the persistence of psychotic experiences (OR=1.72, 95% CI 1.44-2.04). However, remission of sleep problems did not predict remission of psychotic experiences (OR=1.041, 95% CI 0.80-1.35). The results indicate that sleep disorders in preadolescence are common and associated with psychotic experiences, although the lack of co-remission raises questions about the mechanism of association. However, given these findings, and existing evidence in later adolescence and adults, further investigation of sleep as a preventative mental health intervention in this age group is warranted.

中文翻译:

睡眠障碍可预测青春期前精神病经历的一年发作、持续性而非缓解:对 ABCD 队列数据的纵向分析

尽管有干预的潜力,但尚未对青春期前睡眠障碍与精神病经历之间的关系进行广泛研究。目前的研究使用青少年大脑认知发展 (ABCD) 队列来解决这种关系,该队列提供了 11,830 名 10 至 11 岁儿童的基线数据;这些 1 年随访数据中的 4910 份也可用。应用一组预先注册的多级回归模型来测试 a) 睡眠障碍是否与基线时的精神病经历有关;b) 基线睡眠障碍可预测随访时的精神病经历;c) 睡眠障碍的持续存在预示着后续精神病体验的持续存在;d) 睡眠障碍的缓解预示着随访时精神病体验的缓解。在控制了潜在的混杂因素后,睡眠障碍与精神病经历横断面相关 (OR=1.40, 95% CI 1.20-1.63),在一年的随访中 (OR=1.32, 95% CI 1.11-1.57),并且睡眠障碍的持续性预测精神病经历的持续性(OR=1.72,95% CI 1.44-2.04)。然而,睡眠问题的缓解并不能预测精神病体验的缓解(OR=1.041,95% CI 0.80-1.35)。结果表明,青春期前的睡眠障碍很常见,并且与精神病经历有关,尽管缺乏共同缓解引发了对关联机制的质疑。然而,鉴于这些发现,以及后期青春期和成人的现有证据,有必要进一步研究睡眠作为该年龄段的预防性心理健康干预措施。40, 95% CI 1.20-1.63),在一年随访时 (OR=1.32, 95% CI 1.11-1.57),睡眠障碍的持续性预测精神病体验的持续性 (OR=1.72, 95% CI 1.44-2.04)。然而,睡眠问题的缓解并不能预测精神病体验的缓解(OR=1.041,95% CI 0.80-1.35)。结果表明,青春期前的睡眠障碍很常见,并且与精神病经历有关,尽管缺乏共同缓解引发了对关联机制的质疑。然而,鉴于这些发现,以及后期青春期和成人的现有证据,有必要进一步研究睡眠作为该年龄段的预防性心理健康干预措施。40, 95% CI 1.20-1.63),在一年随访时 (OR=1.32, 95% CI 1.11-1.57),睡眠障碍的持续性预测精神病体验的持续性 (OR=1.72, 95% CI 1.44-2.04)。然而,睡眠问题的缓解并不能预测精神病体验的缓解(OR=1.041,95% CI 0.80-1.35)。结果表明,青春期前的睡眠障碍很常见,并且与精神病经历有关,尽管缺乏共同缓解引发了对关联机制的质疑。然而,鉴于这些发现,以及后期青春期和成人的现有证据,有必要进一步研究睡眠作为该年龄段的预防性心理健康干预措施。并且睡眠障碍的持续性预测了精神病体验的持续性(OR=1.72,95% CI 1.44-2.04)。然而,睡眠问题的缓解并不能预测精神病体验的缓解(OR=1.041,95% CI 0.80-1.35)。结果表明,青春期前的睡眠障碍很常见,并且与精神病经历有关,尽管缺乏共同缓解引发了对关联机制的质疑。然而,鉴于这些发现,以及后期青春期和成人的现有证据,有必要进一步研究睡眠作为该年龄段的预防性心理健康干预措施。并且睡眠障碍的持续性预测了精神病体验的持续性(OR=1.72,95% CI 1.44-2.04)。然而,睡眠问题的缓解并不能预测精神病体验的缓解(OR=1.041,95% CI 0.80-1.35)。结果表明,青春期前的睡眠障碍很常见,并且与精神病经历有关,尽管缺乏共同缓解引发了对关联机制的质疑。然而,鉴于这些发现,以及后期青春期和成人的现有证据,有必要进一步研究睡眠作为该年龄段的预防性心理健康干预措施。结果表明,青春期前的睡眠障碍很常见,并且与精神病经历有关,尽管缺乏共同缓解引发了对关联机制的质疑。然而,鉴于这些发现,以及后期青春期和成人的现有证据,有必要进一步研究睡眠作为该年龄段的预防性心理健康干预措施。结果表明,青春期前的睡眠障碍很常见,并且与精神病经历有关,尽管缺乏共同缓解引发了对关联机制的质疑。然而,鉴于这些发现,以及后期青春期和成人的现有证据,有必要进一步研究睡眠作为该年龄段的预防性心理健康干预措施。
更新日期:2021-09-09
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