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Nanotechnology-Based Strategies for Berberine Delivery System in Cancer Treatment: Pulling Strings to Keep Berberine in Power
Frontiers in Molecular Biosciences ( IF 5 ) Pub Date : 2020-12-11 , DOI: 10.3389/fmolb.2020.624494
Muhammad Javed Iqbal , Cristina Quispe , Zeeshan Javed , Haleema Sadia , Qamar Raza Qadri , Shahid Raza , Bahare Salehi , Natália Cruz-Martins , Zeinab Abdulwanis Mohamed , Mohammed Sani Jaafaru , Ahmad Faizal Abdull Razis , Javad Sharifi-Rad

Cancer is a multifactorial disease characterized by complex molecular landscape and altered cell pathways that results in an abnormal cell growth. Natural compounds are target-specific and pose a limited cytotoxicity; therefore, can aid in the development of new therapeutic interventions for the treatment of this versatile disease. Berberine is a member of the protoberberine alkaloids family, mainly present in the root, stem, and bark of various trees, and has a reputed anticancer activity. Nonetheless, the limited bioavailability and low absorption rate are the two major hindrances following berberine administration as only 0.5% of ingested berberine absorbed in small intestine while this percentage is further decreased to 0.35%, when enter in systemic circulation. Nano-based formulation is believed to be an ideal candidate to increase absorption percentage as at nano scale level, compounds can absorb rapidly in gut. Nanotechnology-based therapeutic approaches have been implemented to overcome such problems, ultimately promoting a higher efficacy in the treatment of a plethora of diseases. This review present and critically discusses the anti-proliferative role of berberine and the nanotechnology-based therapeutic strategies used for the nano-scale delivery of berberine. Finally, the current approaches and promising perspectives of latest delivery of this alkaloid are also critically analyzed and discussed.



中文翻译:

基于纳米技术的黄连素递送系统在癌症治疗中的策略:拉动束缚,保持黄连素的力量

癌症是一种多因素疾病,其特征在于复杂的分子格局和改变的细胞途径,导致异常的细胞生长。天然化合物具有靶标特异性,并具有有限的细胞毒性。因此,可以帮助开发新的治疗手段来治疗这种多才多艺的疾病。小ber碱是原小ber碱生物碱家族的成员,主要存在于各种树木的根,茎和树皮中,并具有著名的抗癌活性。尽管如此,黄连素施用后的两个主要障碍是有限的生物利用度和低吸收率,因为进入全身循环时,摄入的黄连素仅占小肠吸收的0.5%,而该百分比进一步降低至0.35%。人们认为基于纳米的制剂是增加吸收百分比的理想候选者,因为在纳米水平上,化合物可以在肠道中快速吸收。已经实施了基于纳米技术的治疗方法来克服这些问题,从而最终在治疗多种疾病中提高了疗效。这篇评论提出并批判性地讨论了小ber碱的抗增殖作用以及用于小-碱纳米级递送的基于纳米技术的治疗策略。最后,还对该类生物碱的最新递送方法和前景进行了严格的分析和讨论。最终提高了治疗多种疾病的功效。这篇评论提出并批判性地讨论了小ber碱的抗增殖作用以及用于小-碱纳米级递送的基于纳米技术的治疗策略。最后,还对该类生物碱的最新递送方法和前景进行了严格的分析和讨论。最终提高了治疗多种疾病的功效。这篇评论提出并批判性地讨论了小ber碱的抗增殖作用以及用于小-碱纳米级递送的基于纳米技术的治疗策略。最后,还对该类生物碱的最新递送方法和前景进行了严格的分析和讨论。

更新日期:2021-01-16
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